Prognostic significance of calcium-related genes in lung adenocarcinoma and the role of TNNC1 in macrophage polarization and erlotinib resistance

Prognostic significance of calcium-related genes in lung adenocarcinoma and the role of TNNC1 in macrophage polarization and erlotinib resistance

BackgroundCalcium signaling is critical in tumorigenesis. This study analyzed the characteristics of a calcium-related prognostic genes (CRPGs) signature in lung adenocarcinoma (LUAD) for prognostic value and explored TNNC1 as a potential therapeutic target for erlotinib resistance.MethodsClinical a...

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Bibliographic Details
Main Authors:	Jian Feng, Zhe Chen, Gaoming Wang, Yu Yao, Xuewen Min, Jing Luo, Kai Xie
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Immunology
Subjects:	lung adenocarcinoma calcium-related genes prognostic signature TNNC1 erlotinib resistance macrophage M2 polarization
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509222/full
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