Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review
Vitamin D deficiency is a problem of endemic proportions. Vitamin D is a major regulator of dopaminergic and serotonergic circuits, pathways implicated in addictive disorders. This scoping review (OSF registered as 67yhb) examines preclinical and clinical studies exploring relationships between vita...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Addiction Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277239252400049X |
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| author | Laya Jalilian-Khave Razi Kitaneh Binah Baht Ysrayl Anna Borelli Melissa C. Funaro Marc N. Potenza Gustavo A. Angarita |
| author_facet | Laya Jalilian-Khave Razi Kitaneh Binah Baht Ysrayl Anna Borelli Melissa C. Funaro Marc N. Potenza Gustavo A. Angarita |
| author_sort | Laya Jalilian-Khave |
| collection | DOAJ |
| description | Vitamin D deficiency is a problem of endemic proportions. Vitamin D is a major regulator of dopaminergic and serotonergic circuits, pathways implicated in addictive disorders. This scoping review (OSF registered as 67yhb) examines preclinical and clinical studies exploring relationships between vitamin D in impulse control disorders, behavioral addictions, and substance use disorders. We searched Ovid MEDLINE, Embase, APA PsycInfo, Cochrane Library, Web of Science, and Scopus databases. We extracted and summarized quantitative and qualitative data through a narrative synthesis and assessed the quality of studies using the Joanna Briggs Institute (JBI) and SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation) criteria. Of 5,442 initial records identified, 28 preclinical and clinical studies were included. For most conditions, we found a negative relationship between vitamin D levels and symptom presence and/or severity. While data suggest a potential beneficial effect of vitamin D on preventing or treating these conditions, there were significant limitations identified by the JBI and SYRCLE assessments. Future studies should include impulse control disorders and other under-explored conditions, address heterogeneity regarding forms, doses, and duration of exposures to vitamin D, and explore vitamin D's potential therapeutic mechanisms. |
| format | Article |
| id | doaj-art-ccc3cf459ec44a35909ae636ae96bead |
| institution | Kabale University |
| issn | 2772-3925 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj-art-ccc3cf459ec44a35909ae636ae96bead2025-01-29T05:02:41ZengElsevierAddiction Neuroscience2772-39252025-03-0114100190Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping reviewLaya Jalilian-Khave0Razi Kitaneh1Binah Baht Ysrayl2Anna Borelli3Melissa C. Funaro4Marc N. Potenza5Gustavo A. Angarita6Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Clinical Neuroscience Research Unit, Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA; Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA; Clinical Neuroscience Research Unit, Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA; Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Clinical Neuroscience Research Unit, Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA; Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USAHarvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CT, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Clinical Neuroscience Research Unit, Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA; Child Study Center, Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Neuroscience, Yale University, New Haven, CT, 06510, USA; Connecticut Council On Problem Gambling, Wethersfield, CT, 06109, USA; Wu Tsai Institute, Yale University, New Haven, CT, 06510, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Clinical Neuroscience Research Unit, Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA; Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA; Corresponding author at: Clinical Neuroscience Research Unit, Connecticut Mental Health Center, 34 Park Street, USA.Vitamin D deficiency is a problem of endemic proportions. Vitamin D is a major regulator of dopaminergic and serotonergic circuits, pathways implicated in addictive disorders. This scoping review (OSF registered as 67yhb) examines preclinical and clinical studies exploring relationships between vitamin D in impulse control disorders, behavioral addictions, and substance use disorders. We searched Ovid MEDLINE, Embase, APA PsycInfo, Cochrane Library, Web of Science, and Scopus databases. We extracted and summarized quantitative and qualitative data through a narrative synthesis and assessed the quality of studies using the Joanna Briggs Institute (JBI) and SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation) criteria. Of 5,442 initial records identified, 28 preclinical and clinical studies were included. For most conditions, we found a negative relationship between vitamin D levels and symptom presence and/or severity. While data suggest a potential beneficial effect of vitamin D on preventing or treating these conditions, there were significant limitations identified by the JBI and SYRCLE assessments. Future studies should include impulse control disorders and other under-explored conditions, address heterogeneity regarding forms, doses, and duration of exposures to vitamin D, and explore vitamin D's potential therapeutic mechanisms.http://www.sciencedirect.com/science/article/pii/S277239252400049XAddictive behaviorsSubstance use disordersDopaminergic neurotransmissionVitamin DImpulsive behaviorsCompulsive behaviors |
| spellingShingle | Laya Jalilian-Khave Razi Kitaneh Binah Baht Ysrayl Anna Borelli Melissa C. Funaro Marc N. Potenza Gustavo A. Angarita Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review Addiction Neuroscience Addictive behaviors Substance use disorders Dopaminergic neurotransmission Vitamin D Impulsive behaviors Compulsive behaviors |
| title | Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review |
| title_full | Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review |
| title_fullStr | Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review |
| title_full_unstemmed | Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review |
| title_short | Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review |
| title_sort | potential roles for vitamin d in preventing and treating impulse control disorders behavioral addictions and substance use disorders a scoping review |
| topic | Addictive behaviors Substance use disorders Dopaminergic neurotransmission Vitamin D Impulsive behaviors Compulsive behaviors |
| url | http://www.sciencedirect.com/science/article/pii/S277239252400049X |
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