Glucagon-Like Peptide-1 Receptor Agonist Protects Dorsal Root Ganglion Neurons against Oxidative Insult

Glucagon-Like Peptide-1 Receptor Agonist Protects Dorsal Root Ganglion Neurons against Oxidative Insult

Objective. Diabetic polyneuropathy (DPN) is one of the most prevalent diabetic complications. We previously demonstrated that exendin-4 (Ex4), a glucagon-like peptide-1 receptor agonist (GLP-1RA), has beneficial effects in animal models of DPN. We hypothesized that GLP-1 signaling would protect neur...

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Main Authors: Mohammad Sarif Mohiuddin, Tatsuhito Himeno, Rieko Inoue, Emiri Miura-Yura, Yuichiro Yamada, Hiromi Nakai-Shimoda, Saeko Asano, Makoto Kato, Mikio Motegi, Masaki Kondo, Yusuke Seino, Shin Tsunekawa, Yoshiro Kato, Atsushi Suzuki, Keiko Naruse, Koichi Kato, Jiro Nakamura, Hideki Kamiya
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2019/9426014
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