TOXICITY AND EFFICACY OF TYROSINE KINASE INHIBITORS IN COMBINATION WITH CHEMOTHERAPY IN PATIENT WITH RESISTANT Ph-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (CASE REPORT AND LITERATURE REVIEW)

TOXICITY AND EFFICACY OF TYROSINE KINASE INHIBITORS IN COMBINATION WITH CHEMOTHERAPY IN PATIENT WITH RESISTANT Ph-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (CASE REPORT AND LITERATURE REVIEW)

A wide range of toxic complications of BCR-ABL tyrosine kinase inhibitors therapy due to non-targeted inhibition of other protein kinases. This is of particular importance in the treatment of patients with Ph-positive lymphoblastic leukemia, who receive, in addition to tyrosine kinase inhibitors, cy...

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Bibliographic Details
Main Authors: K. I. Zarubina, E. N. Parovichnikova, O. A. Gavrilina, A. N. Sokolov, V. V. Troitskaya, L. A. Kuzmina, V. E. Mamonov, G. M. Galstyan, V. G. Savchenko
Format: Article
Language:Russian
Published: ABV-press 2017-10-01
Series:Онкогематология
Subjects:
ph-positive acute lymphoblastic leukemia
tyrosine kinase inhibitors
selectivity
combined toxicity
t315i mutation
imatinib
nilotinib
dasatinib
axitinib
ponatinib
blinatumomab
Online Access:https://oncohematology.abvpress.ru/ongm/article/view/257
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