Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm
Abdominal aortic aneurysm (AAA) is a common disease with a large heritable component. There is a need to improve our understanding of AAA pathogenesis in order to develop novel treatment paradigms. Genomewide association studies have revolutionized research into the genetic variants that underpin th...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/852829 |
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| _version_ | 1832561733261066240 |
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| author | Seamus C. Harrison Anastasia Z. Kalea Michael V. Holmes Obi Agu Steve E. Humphries |
| author_facet | Seamus C. Harrison Anastasia Z. Kalea Michael V. Holmes Obi Agu Steve E. Humphries |
| author_sort | Seamus C. Harrison |
| collection | DOAJ |
| description | Abdominal aortic aneurysm (AAA) is a common disease with a large heritable component. There is a need to improve our understanding of AAA pathogenesis in order to develop novel treatment paradigms. Genomewide association studies have revolutionized research into the genetic variants that underpin the development of many complex diseases including AAA. This article reviews the progress that has been made to date in this regard, including mechanisms by which loci identified by GWAS may contribute to the development of AAA. It also highlights potential post-GWAS analytical strategies to improve our understanding of the disease further. |
| format | Article |
| id | doaj-art-ccbacb27f5f645c897a383534dc80563 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-ccbacb27f5f645c897a383534dc805632025-02-03T01:24:22ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/852829852829Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic AneurysmSeamus C. Harrison0Anastasia Z. Kalea1Michael V. Holmes2Obi Agu3Steve E. Humphries4Centre for Cardiovascular Genetics, BHF Laboratories,The Rayne Building, Department of Medicine, University College London (UCL), 5 University Street, London WC1E 6JF, UKCentre for Cardiovascular Genetics, BHF Laboratories,The Rayne Building, Department of Medicine, University College London (UCL), 5 University Street, London WC1E 6JF, UKGenetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UKDepartment of Vascular Surgery, University College London Hospital, London NW1 2BU, UKCentre for Cardiovascular Genetics, BHF Laboratories,The Rayne Building, Department of Medicine, University College London (UCL), 5 University Street, London WC1E 6JF, UKAbdominal aortic aneurysm (AAA) is a common disease with a large heritable component. There is a need to improve our understanding of AAA pathogenesis in order to develop novel treatment paradigms. Genomewide association studies have revolutionized research into the genetic variants that underpin the development of many complex diseases including AAA. This article reviews the progress that has been made to date in this regard, including mechanisms by which loci identified by GWAS may contribute to the development of AAA. It also highlights potential post-GWAS analytical strategies to improve our understanding of the disease further.http://dx.doi.org/10.1155/2012/852829 |
| spellingShingle | Seamus C. Harrison Anastasia Z. Kalea Michael V. Holmes Obi Agu Steve E. Humphries Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm Cardiology Research and Practice |
| title | Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm |
| title_full | Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm |
| title_fullStr | Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm |
| title_full_unstemmed | Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm |
| title_short | Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm |
| title_sort | genomic research to identify novel pathways in the development of abdominal aortic aneurysm |
| url | http://dx.doi.org/10.1155/2012/852829 |
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