Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases
Background. Kawasaki disease (KD) is an inflammatory vasculitis and is the most common cause of acquired childhood heart disease in developed countries. Current treatment with intravenous immunoglobulin (IVIG) is often ineffective in patients with delayed or refractory disease. We present a case of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2020/6249013 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568106999873536 |
|---|---|
| author | Maegan Williams Lakshmi Nagaraju Mark Gorelik |
| author_facet | Maegan Williams Lakshmi Nagaraju Mark Gorelik |
| author_sort | Maegan Williams |
| collection | DOAJ |
| description | Background. Kawasaki disease (KD) is an inflammatory vasculitis and is the most common cause of acquired childhood heart disease in developed countries. Current treatment with intravenous immunoglobulin (IVIG) is often ineffective in patients with delayed or refractory disease. We present a case of combination anticytokine therapy in an infant with delayed and refractory KD. Case Presentation. A 3-month-old infant presented with refractory KD with giant aneurysms after a delayed diagnosis of one month. Use of combination anticytokine therapy led to resolution of giant aneurysms over approximately 6 months. Conclusions. Our case is unique in effective use of anticytokine therapy in very delayed disease with giant aneurysms. Additionally, we review other cases for a broader perspective. Prospective study of anticytokine therapy for patients with giant aneurysms may be warranted. |
| format | Article |
| id | doaj-art-ccac617b22aa4d0cbe12a794b9181e52 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-ccac617b22aa4d0cbe12a794b9181e522025-02-03T00:59:44ZengWileyCase Reports in Rheumatology2090-68892090-68972020-01-01202010.1155/2020/62490136249013Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar CasesMaegan Williams0Lakshmi Nagaraju1Mark Gorelik2Division of General Pediatrics, Children’s Hospital of San Antonio, Baylor College of Medicine, 333 N Santa Rosa St, San Antonio, TX, USADivision of Cardiology, Children’s Hospital of San Antonio, Baylor College of Medicine, 333 N Santa Rosa St, San Antonio, TX, USADivision of Allergy, Immunology and Rheumatology, Children’s Hospital of San Antonio, Baylor College of Medicine, 333 N Santa Rosa St, San Antonio, TX, USABackground. Kawasaki disease (KD) is an inflammatory vasculitis and is the most common cause of acquired childhood heart disease in developed countries. Current treatment with intravenous immunoglobulin (IVIG) is often ineffective in patients with delayed or refractory disease. We present a case of combination anticytokine therapy in an infant with delayed and refractory KD. Case Presentation. A 3-month-old infant presented with refractory KD with giant aneurysms after a delayed diagnosis of one month. Use of combination anticytokine therapy led to resolution of giant aneurysms over approximately 6 months. Conclusions. Our case is unique in effective use of anticytokine therapy in very delayed disease with giant aneurysms. Additionally, we review other cases for a broader perspective. Prospective study of anticytokine therapy for patients with giant aneurysms may be warranted.http://dx.doi.org/10.1155/2020/6249013 |
| spellingShingle | Maegan Williams Lakshmi Nagaraju Mark Gorelik Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases Case Reports in Rheumatology |
| title | Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases |
| title_full | Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases |
| title_fullStr | Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases |
| title_full_unstemmed | Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases |
| title_short | Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases |
| title_sort | complete regression of giant aneurysms in an infant with delayed diagnosis and refractory kawasaki disease via combination anticytokine therapy case report and review of similar cases |
| url | http://dx.doi.org/10.1155/2020/6249013 |
| work_keys_str_mv | AT maeganwilliams completeregressionofgiantaneurysmsinaninfantwithdelayeddiagnosisandrefractorykawasakidiseaseviacombinationanticytokinetherapycasereportandreviewofsimilarcases AT lakshminagaraju completeregressionofgiantaneurysmsinaninfantwithdelayeddiagnosisandrefractorykawasakidiseaseviacombinationanticytokinetherapycasereportandreviewofsimilarcases AT markgorelik completeregressionofgiantaneurysmsinaninfantwithdelayeddiagnosisandrefractorykawasakidiseaseviacombinationanticytokinetherapycasereportandreviewofsimilarcases |