A VioA Variant Activates Antibiotic Streptogramins in the Heterologous Host <i>Streptomyces</i> sp. OUC20-O

A VioA Variant Activates Antibiotic Streptogramins in the Heterologous Host <i>Streptomyces</i> sp. OUC20-O

Heterologous expression of the G231L variant of VioA into 16 strains of marine-derived <i>Streptomyces</i>, combined with bioactivity tracking, leads to the activation of seven antibiotic streptogramins (<b>1</b>–<b>7</b>) in <i>Streptomyces</i> sp. OU...

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Bibliographic Details
Main Authors: Jie Shan, Liangguang Yue, Luyao Xu, Runyi Wang, Qingzhou Meng, Jun Feng, Joon-Hee Lee, Ming Lu, Huayue Li
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Marine Drugs
Subjects:
heterologous expression
marine-derived <i>Streptomyces</i>
multidrug-resistant
antibiotic
streptogramin
Online Access:https://www.mdpi.com/1660-3397/23/5/205
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