Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers
Abstract Real-time monitoring of hydration biomarkers in tandem with biophysical markers can offer valuable physiological insights about heat stress and related thermoregulatory response. These metrics have been challenging to achieve with wearable sensors. Here we present a closed-loop electrochemi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-025-01466-9 |
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| author | Julia C. Spinelli Brandon J. Suleski Donald E. Wright Joseph L. Grow Gabriel R. Fagans Maura J. Buckley Da Som Yang Kaitao Yang Steven M. Beil Jessica C. Wallace Thomas S. DiZoglio Jeffrey B. Model Shirley Love David E. Macintosh Alan P. Scarth Matthew T. Marrapode Corinna Serviente Raudel Avila Barrak K. Alahmad Michael A. Busa John A. Wright Weihua Li Douglas J. Casa John A. Rogers Stephen P. Lee Roozbeh Ghaffari Alexander J. Aranyosi |
| author_facet | Julia C. Spinelli Brandon J. Suleski Donald E. Wright Joseph L. Grow Gabriel R. Fagans Maura J. Buckley Da Som Yang Kaitao Yang Steven M. Beil Jessica C. Wallace Thomas S. DiZoglio Jeffrey B. Model Shirley Love David E. Macintosh Alan P. Scarth Matthew T. Marrapode Corinna Serviente Raudel Avila Barrak K. Alahmad Michael A. Busa John A. Wright Weihua Li Douglas J. Casa John A. Rogers Stephen P. Lee Roozbeh Ghaffari Alexander J. Aranyosi |
| author_sort | Julia C. Spinelli |
| collection | DOAJ |
| description | Abstract Real-time monitoring of hydration biomarkers in tandem with biophysical markers can offer valuable physiological insights about heat stress and related thermoregulatory response. These metrics have been challenging to achieve with wearable sensors. Here we present a closed-loop electrochemical/biophysical wearable sensing device and algorithms that directly measure whole-body sweat loss, sweating rate, sodium concentration, and sodium loss with electrode arrays embedded in a microfluidic channel. The device contains two temperature sensors for skin temperature and thermal flux recordings, and an accelerometer for real-time monitoring of activity level. An onboard haptic module enables vibratory feedback cues to the wearer once critical sweat loss thresholds are reached. Data is stored onboard in memory and autonomously transmitted via Bluetooth to a smartphone and cloud portal. Field studies conducted in physically demanding activities demonstrate the key capabilities of this platform to inform hydration interventions in highly challenging real-world settings. |
| format | Article |
| id | doaj-art-cc91ea12c0fa40c493804815e0967f68 |
| institution | Kabale University |
| issn | 2398-6352 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-cc91ea12c0fa40c493804815e0967f682025-02-02T12:43:41ZengNature Portfolionpj Digital Medicine2398-63522025-02-018111210.1038/s41746-025-01466-9Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workersJulia C. Spinelli0Brandon J. Suleski1Donald E. Wright2Joseph L. Grow3Gabriel R. Fagans4Maura J. Buckley5Da Som Yang6Kaitao Yang7Steven M. Beil8Jessica C. Wallace9Thomas S. DiZoglio10Jeffrey B. Model11Shirley Love12David E. Macintosh13Alan P. Scarth14Matthew T. Marrapode15Corinna Serviente16Raudel Avila17Barrak K. Alahmad18Michael A. Busa19John A. Wright20Weihua Li21Douglas J. Casa22John A. Rogers23Stephen P. Lee24Roozbeh Ghaffari25Alexander J. Aranyosi26Epicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncQuerrey-Simpson Institute for Bioelectronics, Northwestern UniversityEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncInstitute for Applied Life Sciences, University of Massachusetts AmherstDepartment of Mechanical Engineering, Rice UniversityDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard UniversityInstitute for Applied Life Sciences, University of Massachusetts AmherstEpicore Biosystems, IncEpicore Biosystems, IncDepartment of Kinesiology, University of ConnecticutQuerrey-Simpson Institute for Bioelectronics, Northwestern UniversityEpicore Biosystems, IncEpicore Biosystems, IncEpicore Biosystems, IncAbstract Real-time monitoring of hydration biomarkers in tandem with biophysical markers can offer valuable physiological insights about heat stress and related thermoregulatory response. These metrics have been challenging to achieve with wearable sensors. Here we present a closed-loop electrochemical/biophysical wearable sensing device and algorithms that directly measure whole-body sweat loss, sweating rate, sodium concentration, and sodium loss with electrode arrays embedded in a microfluidic channel. The device contains two temperature sensors for skin temperature and thermal flux recordings, and an accelerometer for real-time monitoring of activity level. An onboard haptic module enables vibratory feedback cues to the wearer once critical sweat loss thresholds are reached. Data is stored onboard in memory and autonomously transmitted via Bluetooth to a smartphone and cloud portal. Field studies conducted in physically demanding activities demonstrate the key capabilities of this platform to inform hydration interventions in highly challenging real-world settings.https://doi.org/10.1038/s41746-025-01466-9 |
| spellingShingle | Julia C. Spinelli Brandon J. Suleski Donald E. Wright Joseph L. Grow Gabriel R. Fagans Maura J. Buckley Da Som Yang Kaitao Yang Steven M. Beil Jessica C. Wallace Thomas S. DiZoglio Jeffrey B. Model Shirley Love David E. Macintosh Alan P. Scarth Matthew T. Marrapode Corinna Serviente Raudel Avila Barrak K. Alahmad Michael A. Busa John A. Wright Weihua Li Douglas J. Casa John A. Rogers Stephen P. Lee Roozbeh Ghaffari Alexander J. Aranyosi Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers npj Digital Medicine |
| title | Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers |
| title_full | Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers |
| title_fullStr | Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers |
| title_full_unstemmed | Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers |
| title_short | Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers |
| title_sort | wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers |
| url | https://doi.org/10.1038/s41746-025-01466-9 |
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