Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review

Advanced heart failure patients commonly suffer from ventricular arrhythmias which can be managed by antiarrhythmic drugs like mexiletine. These ventricular arrhythmias can be complicated by illicit drug use which alter outcomes and can potentially impact the patient-physician relationship through c...

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Main Authors: Sumit Sohal, Mina Sous, Gauri Pethe, Shanmugha V. Padmanabhan, Rajesh Akbari, Shahriar Dadkhah
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2021/7134394
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author Sumit Sohal
Mina Sous
Gauri Pethe
Shanmugha V. Padmanabhan
Rajesh Akbari
Shahriar Dadkhah
author_facet Sumit Sohal
Mina Sous
Gauri Pethe
Shanmugha V. Padmanabhan
Rajesh Akbari
Shahriar Dadkhah
author_sort Sumit Sohal
collection DOAJ
description Advanced heart failure patients commonly suffer from ventricular arrhythmias which can be managed by antiarrhythmic drugs like mexiletine. These ventricular arrhythmias can be complicated by illicit drug use which alter outcomes and can potentially impact the patient-physician relationship through countertransference. However, mexiletine can lead to false positive urine drug screen testing for amphetamine, and these false-positive urine drug screen test results can affect the decision-making process. Health care providers should be aware of this fact and should either use confirmatory testing or look for confounding compounds in patients who deny using illicit substances and have a positive urine drug screen. Our patient is 64 years old who arrived at the emergency department after experiencing a shock by his intracardiac defibrillator. The patient tested positive for amphetamine on his urine drug screen and was later ruled out by confirmatory quantitative testing.
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spelling doaj-art-cc7326d517814c9a93712fb57ffef0d82025-02-03T05:43:41ZengWileyCase Reports in Medicine1687-96352021-01-01202110.1155/2021/7134394Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case ReviewSumit Sohal0Mina Sous1Gauri Pethe2Shanmugha V. Padmanabhan3Rajesh Akbari4Shahriar Dadkhah5Division of Cardiovascular DiseasesDepartment of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDivision of Cardiovascular DiseasesAdvanced heart failure patients commonly suffer from ventricular arrhythmias which can be managed by antiarrhythmic drugs like mexiletine. These ventricular arrhythmias can be complicated by illicit drug use which alter outcomes and can potentially impact the patient-physician relationship through countertransference. However, mexiletine can lead to false positive urine drug screen testing for amphetamine, and these false-positive urine drug screen test results can affect the decision-making process. Health care providers should be aware of this fact and should either use confirmatory testing or look for confounding compounds in patients who deny using illicit substances and have a positive urine drug screen. Our patient is 64 years old who arrived at the emergency department after experiencing a shock by his intracardiac defibrillator. The patient tested positive for amphetamine on his urine drug screen and was later ruled out by confirmatory quantitative testing.http://dx.doi.org/10.1155/2021/7134394
spellingShingle Sumit Sohal
Mina Sous
Gauri Pethe
Shanmugha V. Padmanabhan
Rajesh Akbari
Shahriar Dadkhah
Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review
Case Reports in Medicine
title Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review
title_full Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review
title_fullStr Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review
title_full_unstemmed Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review
title_short Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review
title_sort mexiletine and false positive urine drug screen for amphetamine a case review
url http://dx.doi.org/10.1155/2021/7134394
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