Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns
To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight <1500 g and a postnatal age >72 hours of life. The diagnostic accuracy of serum calprotectin was compared...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/291085 |
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| author | Gianluca Terrin Annalisa Passariello Francesco Manguso Gennaro Salvia Luciano Rapacciuolo Francesco Messina Francesco Raimondi Roberto Berni Canani |
| author_facet | Gianluca Terrin Annalisa Passariello Francesco Manguso Gennaro Salvia Luciano Rapacciuolo Francesco Messina Francesco Raimondi Roberto Berni Canani |
| author_sort | Gianluca Terrin |
| collection | DOAJ |
| description | To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight <1500 g and a postnatal age >72
hours of life. The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-total-neutrophil ratio, platelet count, and C-reactive protein). We found that the serum calprotectin concentration was significantly higher (P<.001) in 62 newborns with confirmed sepsis (3.1±1.0
μg/mL) than in either 29 noninfected subjects (1.1±0.3 μg/ml) or 110 healthy controls (0.91±0.58 μg/ml). The diagnostic accuracy of serum calprotectin was greater (sensitivity 89%, specificity 96%) than that of the traditional markers of sepsis. In conclusion, serum calprotectin is an accurate marker of sepsis in very low birth weight newborns. |
| format | Article |
| id | doaj-art-cc60efccbe5441f88d00a72dedac668e |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-cc60efccbe5441f88d00a72dedac668e2025-02-03T05:45:30ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/291085291085Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight NewbornsGianluca Terrin0Annalisa Passariello1Francesco Manguso2Gennaro Salvia3Luciano Rapacciuolo4Francesco Messina5Francesco Raimondi6Roberto Berni Canani7Department of Women Health and Territorial Medicine, University of Rome “La Sapienza”, 00185 Rome, ItalyDepartment of Pediatrics, University of Naples “Federico II”, 80131 Naples, ItalyA. Cardarelli Hospital, 80131 Naples, ItalyNeonatal Unit, “Fatebenefratelli” Hospital, 80123 Naples, ItalyDepartment of Pediatrics, University of Naples “Federico II”, 80131 Naples, ItalyNeonatal Unit, “Villa Betania” Evangelical Hospital, 80100 Naples, ItalyDepartment of Pediatrics, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Pediatrics, University of Naples “Federico II”, 80131 Naples, ItalyTo determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight <1500 g and a postnatal age >72 hours of life. The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-total-neutrophil ratio, platelet count, and C-reactive protein). We found that the serum calprotectin concentration was significantly higher (P<.001) in 62 newborns with confirmed sepsis (3.1±1.0 μg/mL) than in either 29 noninfected subjects (1.1±0.3 μg/ml) or 110 healthy controls (0.91±0.58 μg/ml). The diagnostic accuracy of serum calprotectin was greater (sensitivity 89%, specificity 96%) than that of the traditional markers of sepsis. In conclusion, serum calprotectin is an accurate marker of sepsis in very low birth weight newborns.http://dx.doi.org/10.1155/2011/291085 |
| spellingShingle | Gianluca Terrin Annalisa Passariello Francesco Manguso Gennaro Salvia Luciano Rapacciuolo Francesco Messina Francesco Raimondi Roberto Berni Canani Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns Clinical and Developmental Immunology |
| title | Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns |
| title_full | Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns |
| title_fullStr | Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns |
| title_full_unstemmed | Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns |
| title_short | Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns |
| title_sort | serum calprotectin an antimicrobial peptide as a new marker for the diagnosis of sepsis in very low birth weight newborns |
| url | http://dx.doi.org/10.1155/2011/291085 |
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