Death of a 29-Year-Old Male from Undifferentiated Sepsis
Tumour necrosis factor alpha inhibitors, such as infliximab, and other biologic agents are associated with increased risk of opportunistic infection, including tuberculosis. Tuberculosis infections associated with infliximab tend to present atypically and can be difficult to diagnose, as they are mo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2016/2478924 |
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| _version_ | 1832556020072710144 |
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| author | Kathryn A. Trebuss Samantha Buttemer Jeffrey S. Wilkinson Josie Xu John P. Rossiter Kieran M. Moore |
| author_facet | Kathryn A. Trebuss Samantha Buttemer Jeffrey S. Wilkinson Josie Xu John P. Rossiter Kieran M. Moore |
| author_sort | Kathryn A. Trebuss |
| collection | DOAJ |
| description | Tumour necrosis factor alpha inhibitors, such as infliximab, and other biologic agents are associated with increased risk of opportunistic infection, including tuberculosis. Tuberculosis infections associated with infliximab tend to present atypically and can be difficult to diagnose, as they are more likely to manifest as extrapulmonary or disseminated disease. The authors report a case involving a 29-year-old male patient who died following 16 days of treatment for undifferentiated sepsis and who was found on autopsy to have widespread disseminated tuberculosis. Prior to the onset of illness, the patient had received infliximab for the treatment of Crohn’s disease. Following discussion of the case, the authors review the definition of adverse events, provide a root cause analysis of the cognitive errors and breakdowns in the health care system that contributed to the reported outcome, and identify opportunities to address these breakdowns and improve patient safety measures for future cases. |
| format | Article |
| id | doaj-art-cc5e5b1805a74b79a438f8fad77773de |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-cc5e5b1805a74b79a438f8fad77773de2025-02-03T05:46:37ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932016-01-01201610.1155/2016/24789242478924Death of a 29-Year-Old Male from Undifferentiated SepsisKathryn A. Trebuss0Samantha Buttemer1Jeffrey S. Wilkinson2Josie Xu3John P. Rossiter4Kieran M. Moore5Queen’s University, Kingston, ON, K7L 3N6, CanadaQueen’s University, Kingston, ON, K7L 3N6, CanadaQueen’s University, Kingston, ON, K7L 3N6, CanadaUniversity of Toronto, Toronto, ON, M5S 1A8, CanadaDepartment of Pathology and Molecular Medicine, Queen’s University and Kingston General Hospital, Kingston, ON, K7L 3N6, CanadaDepartment of Family Medicine and Emergency Medicine, Queen’s University, Kingston, ON, K7L 3N6, CanadaTumour necrosis factor alpha inhibitors, such as infliximab, and other biologic agents are associated with increased risk of opportunistic infection, including tuberculosis. Tuberculosis infections associated with infliximab tend to present atypically and can be difficult to diagnose, as they are more likely to manifest as extrapulmonary or disseminated disease. The authors report a case involving a 29-year-old male patient who died following 16 days of treatment for undifferentiated sepsis and who was found on autopsy to have widespread disseminated tuberculosis. Prior to the onset of illness, the patient had received infliximab for the treatment of Crohn’s disease. Following discussion of the case, the authors review the definition of adverse events, provide a root cause analysis of the cognitive errors and breakdowns in the health care system that contributed to the reported outcome, and identify opportunities to address these breakdowns and improve patient safety measures for future cases.http://dx.doi.org/10.1155/2016/2478924 |
| spellingShingle | Kathryn A. Trebuss Samantha Buttemer Jeffrey S. Wilkinson Josie Xu John P. Rossiter Kieran M. Moore Death of a 29-Year-Old Male from Undifferentiated Sepsis Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Death of a 29-Year-Old Male from Undifferentiated Sepsis |
| title_full | Death of a 29-Year-Old Male from Undifferentiated Sepsis |
| title_fullStr | Death of a 29-Year-Old Male from Undifferentiated Sepsis |
| title_full_unstemmed | Death of a 29-Year-Old Male from Undifferentiated Sepsis |
| title_short | Death of a 29-Year-Old Male from Undifferentiated Sepsis |
| title_sort | death of a 29 year old male from undifferentiated sepsis |
| url | http://dx.doi.org/10.1155/2016/2478924 |
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