HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic im...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/297073 |
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| _version_ | 1832553359063646208 |
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| author | Vera Rebmann Fabiola da Silva Nardi Bettina Wagner Peter A. Horn |
| author_facet | Vera Rebmann Fabiola da Silva Nardi Bettina Wagner Peter A. Horn |
| author_sort | Vera Rebmann |
| collection | DOAJ |
| description | HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy. |
| format | Article |
| id | doaj-art-cc5536037afb49beb64f41d9349ee207 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cc5536037afb49beb64f41d9349ee2072025-02-03T05:54:11ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/297073297073HLA-G as a Tolerogenic Molecule in Transplantation and PregnancyVera Rebmann0Fabiola da Silva Nardi1Bettina Wagner2Peter A. Horn3Institute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, GermanyInstitute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, GermanyInstitute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, GermanyInstitute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, GermanyHLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.http://dx.doi.org/10.1155/2014/297073 |
| spellingShingle | Vera Rebmann Fabiola da Silva Nardi Bettina Wagner Peter A. Horn HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy Journal of Immunology Research |
| title | HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy |
| title_full | HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy |
| title_fullStr | HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy |
| title_full_unstemmed | HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy |
| title_short | HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy |
| title_sort | hla g as a tolerogenic molecule in transplantation and pregnancy |
| url | http://dx.doi.org/10.1155/2014/297073 |
| work_keys_str_mv | AT verarebmann hlagasatolerogenicmoleculeintransplantationandpregnancy AT fabioladasilvanardi hlagasatolerogenicmoleculeintransplantationandpregnancy AT bettinawagner hlagasatolerogenicmoleculeintransplantationandpregnancy AT peterahorn hlagasatolerogenicmoleculeintransplantationandpregnancy |