Comparison between Levobupivacaine and Levobupivacaine with Clonidine in Erector Spinae Plane Block in Patients undergoing open Cholecystectomy: A Prospective Randomized Double Blinded Study
Background: Erector spinae plane (ESP) block is effective for post-operative analgesia in thoracic and abdominal surgeries. There is minimal experience with clonidine (alpha2 agonist) as an adjuvant to levobupivacaine in ESP block. Objective: The objective of the present study is to compare the du...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dr. Annil Mahajan
2025-04-01
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| Series: | JK Science |
| Subjects: | |
| Online Access: | http://journal.jkscience.org/index.php/JK-Science/article/view/353 |
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| Summary: | Background: Erector spinae plane (ESP) block is effective for post-operative analgesia in thoracic and abdominal surgeries. There is minimal experience with clonidine (alpha2 agonist) as an adjuvant to levobupivacaine in ESP block.
Objective: The objective of the present study is to compare the duration of postoperative analgesia between levobupivacaine and levobupivacaine with clonidine in open cholecystectomy following ESP block.
Material and Methods: One hundred patients, randomly divided into two groups, undergoing open cholecystectomy under general anaesthesia (GA), were given ESP block 20 min before administration of GA. Group L received 19 ml of 0.25% levobupivacaine with 1 ml of normal saline and group LC received clonidine (1.5 mcg/ kg) prepared in 1 ml of normal saline as adjuvant with 19 ml of 0.25% levobupivacaine for ESP block. In the postoperative period, the duration and requirement of analgesia were recorded.
Results: Duration of post-operative analgesia in group LC was 595.78 ± 71.5 min compared to 357.2 ± 18.14 min in group L. (p<0.0001). The requirement of analgesic in the first 24 hours was also significantly less in group LC (p<0.0001).
Conclusion: Clonidine as adjuvant with levobupivacaine in erector spinae plane block provides longer duration of analgesia and reduces analgesic requirement postoperatively without any significant adverse effects.
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| ISSN: | 0972-1177 |