Overview of (1→3)-β-D-glucan immunobiology
Glucans are (1→3)-β-D-glucose polymers that are found in the cell wall of fungi, bacteria and plants. Glucans are known to stim ulate humoral and cell-mediated immunity in humans and animals. In addition to the potent immune stimulatory effects of (1→3)-β-D-glucans, there are a number of toxicologic...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1997-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791550 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554455768236032 |
|---|---|
| author | David L. Williams |
| author_facet | David L. Williams |
| author_sort | David L. Williams |
| collection | DOAJ |
| description | Glucans are (1→3)-β-D-glucose polymers that are found in the cell wall of fungi, bacteria and plants. Glucans are known to stim ulate humoral and cell-mediated immunity in humans and animals. In addition to the potent immune stimulatory effects of (1→3)-β-D-glucans, there are a number of toxicological effects associated with exposure to the water-insoluble, microparticulate form of the polymer. Recent investigations have suggested a potential role for (1→3)-β-D-glucans in inhalational toxicity. Specifically, (1→3)-β-D-glucans have been implicated in the symptomatology associated with ‘sick building’ syndrome. The mechanisms by which
(1→3)-β-D-glucans mediate immune stimulation and, perhaps, toxicity are currently under investigation. It is now established that (1→3)-β-D-glucans are recognized by macrophages and, perhaps, neutrophils and natural killer cells via a (1→3)-β-glucan specific receptor. Following receptor binding, glucan modulates macrophage cytokine expression. Here we review the chemistry, immunobiology and toxicity of (1→3)-β-D-glucans and how it may relate to effects caused by inhalation. |
| format | Article |
| id | doaj-art-cc3f6e62b6ff42d7a66a7ffc16cd886a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cc3f6e62b6ff42d7a66a7ffc16cd886a2025-02-03T05:51:28ZengWileyMediators of Inflammation0962-93511466-18611997-01-016424725010.1080/09629359791550Overview of (1→3)-β-D-glucan immunobiologyDavid L. Williams0Department of Surgery, James H. Quillen College of Medicine, Box 70575, Johnson City 37614-0002, TN, USAGlucans are (1→3)-β-D-glucose polymers that are found in the cell wall of fungi, bacteria and plants. Glucans are known to stim ulate humoral and cell-mediated immunity in humans and animals. In addition to the potent immune stimulatory effects of (1→3)-β-D-glucans, there are a number of toxicological effects associated with exposure to the water-insoluble, microparticulate form of the polymer. Recent investigations have suggested a potential role for (1→3)-β-D-glucans in inhalational toxicity. Specifically, (1→3)-β-D-glucans have been implicated in the symptomatology associated with ‘sick building’ syndrome. The mechanisms by which (1→3)-β-D-glucans mediate immune stimulation and, perhaps, toxicity are currently under investigation. It is now established that (1→3)-β-D-glucans are recognized by macrophages and, perhaps, neutrophils and natural killer cells via a (1→3)-β-glucan specific receptor. Following receptor binding, glucan modulates macrophage cytokine expression. Here we review the chemistry, immunobiology and toxicity of (1→3)-β-D-glucans and how it may relate to effects caused by inhalation.http://dx.doi.org/10.1080/09629359791550 |
| spellingShingle | David L. Williams Overview of (1→3)-β-D-glucan immunobiology Mediators of Inflammation |
| title | Overview of (1→3)-β-D-glucan immunobiology |
| title_full | Overview of (1→3)-β-D-glucan immunobiology |
| title_fullStr | Overview of (1→3)-β-D-glucan immunobiology |
| title_full_unstemmed | Overview of (1→3)-β-D-glucan immunobiology |
| title_short | Overview of (1→3)-β-D-glucan immunobiology |
| title_sort | overview of 1 3 β d glucan immunobiology |
| url | http://dx.doi.org/10.1080/09629359791550 |
| work_keys_str_mv | AT davidlwilliams overviewof13bdglucanimmunobiology |