Causal association of sex hormone-related traits with Alzheimer’s disease: a multivariable and network Mendelian randomization analysis

Causal association of sex hormone-related traits with Alzheimer’s disease: a multivariable and network Mendelian randomization analysis

BackgroundAlthough studies have demonstrated a correlation between sex hormone-related traits [such as sex hormone binding globulin (SHBG) and testosterone] and Alzheimer’s Disease (AD), the link remains uncertain due to the intricacies of AD pathology. The study aimed to investigate the possible ca...

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Bibliographic Details
Main Authors:	Yan Zhang, Zhen-dong Sun, Yu-shen Yang, Wei-dong Fu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Neurology
Subjects:	Alzheimer’s disease sex hormone-binding globulin (SHBG) testosterone neurodegenerative disease Mendelian randomization
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1391182/full
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