Corneal Allografts: Factors for and against Acceptance
Cornea is one of the most commonly transplanted tissues worldwide. However, it is usually omitted in the field of transplantology. Transplantation of the cornea is performed to treat many ocular diseases. It restores eyesight significantly improving the quality of life. Advancements in banking of ex...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5372090 |
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| author | Justyna Sakowska Paulina Glasner Maciej Zieliński Piotr Trzonkowski Leopold Glasner |
| author_facet | Justyna Sakowska Paulina Glasner Maciej Zieliński Piotr Trzonkowski Leopold Glasner |
| author_sort | Justyna Sakowska |
| collection | DOAJ |
| description | Cornea is one of the most commonly transplanted tissues worldwide. However, it is usually omitted in the field of transplantology. Transplantation of the cornea is performed to treat many ocular diseases. It restores eyesight significantly improving the quality of life. Advancements in banking of explanted corneas and progressive surgical techniques increased availability and outcomes of transplantation. Despite the vast growth in the field of transplantation laboratory testing, standards for corneal transplantation still do not include HLA typing or alloantibody detection. This standard practice is based on immune privilege dogma that accounts for high success rates of corneal transplantation. However, the increasing need for retransplantation in high-risk patients with markedly higher risk of rejection causes ophthalmology transplantation centers to reevaluate their standard algorithms. In this review we discuss immune privilege mechanisms influencing the allograft acceptance and factors disrupting the natural immunosuppressive environment of the eye. Current developments in testing and immunosuppressive treatments (including cell therapies), when applied in corneal transplantation, may give very good results, decrease the possibility of rejection, and reduce the need for retransplantation, which is fairly frequent nowadays. |
| format | Article |
| id | doaj-art-cc2a026e166340e5ba54d7a5437888e8 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cc2a026e166340e5ba54d7a5437888e82025-08-20T02:19:58ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/53720905372090Corneal Allografts: Factors for and against AcceptanceJustyna Sakowska0Paulina Glasner1Maciej Zieliński2Piotr Trzonkowski3Leopold Glasner4Department of Medical Immunology, Medical University of Gdańsk, Dębinki 7 Street, Building 27, 80-211 Gdańsk, PolandDepartment of Anaesthesiology and Intensive Care, Medical University of Gdańsk, Mariana Smoluchowskiego 17 Street, 80-214 Gdańsk, PolandDepartment of Medical Immunology, Medical University of Gdańsk, Dębinki 7 Street, Building 27, 80-211 Gdańsk, PolandDepartment of Medical Immunology, Medical University of Gdańsk, Dębinki 7 Street, Building 27, 80-211 Gdańsk, PolandDepartment of Ophthalmology, Medical University of Gdańsk, Mariana Smoluchowskiego 17 Street, 80-214 Gdańsk, PolandCornea is one of the most commonly transplanted tissues worldwide. However, it is usually omitted in the field of transplantology. Transplantation of the cornea is performed to treat many ocular diseases. It restores eyesight significantly improving the quality of life. Advancements in banking of explanted corneas and progressive surgical techniques increased availability and outcomes of transplantation. Despite the vast growth in the field of transplantation laboratory testing, standards for corneal transplantation still do not include HLA typing or alloantibody detection. This standard practice is based on immune privilege dogma that accounts for high success rates of corneal transplantation. However, the increasing need for retransplantation in high-risk patients with markedly higher risk of rejection causes ophthalmology transplantation centers to reevaluate their standard algorithms. In this review we discuss immune privilege mechanisms influencing the allograft acceptance and factors disrupting the natural immunosuppressive environment of the eye. Current developments in testing and immunosuppressive treatments (including cell therapies), when applied in corneal transplantation, may give very good results, decrease the possibility of rejection, and reduce the need for retransplantation, which is fairly frequent nowadays.http://dx.doi.org/10.1155/2021/5372090 |
| spellingShingle | Justyna Sakowska Paulina Glasner Maciej Zieliński Piotr Trzonkowski Leopold Glasner Corneal Allografts: Factors for and against Acceptance Journal of Immunology Research |
| title | Corneal Allografts: Factors for and against Acceptance |
| title_full | Corneal Allografts: Factors for and against Acceptance |
| title_fullStr | Corneal Allografts: Factors for and against Acceptance |
| title_full_unstemmed | Corneal Allografts: Factors for and against Acceptance |
| title_short | Corneal Allografts: Factors for and against Acceptance |
| title_sort | corneal allografts factors for and against acceptance |
| url | http://dx.doi.org/10.1155/2021/5372090 |
| work_keys_str_mv | AT justynasakowska cornealallograftsfactorsforandagainstacceptance AT paulinaglasner cornealallograftsfactorsforandagainstacceptance AT maciejzielinski cornealallograftsfactorsforandagainstacceptance AT piotrtrzonkowski cornealallograftsfactorsforandagainstacceptance AT leopoldglasner cornealallograftsfactorsforandagainstacceptance |