PLATELET HEMOSTASIS DYNAMICS IN SIMVASTATINTREATED PATIENTS WITH ARTERIAL HYPERTENSION AND DYSLIPIDEMIA
Aim: To assess simvastatin effectiveness in lipid profile and platelet activity correction among patients with arterial hypertension (AH) and dyslipidemia. Material and methods. In total, 34 patients received simvastatin for 4 months. The dynamics of lipid profile, lipid peroxidation in plasma and p...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2010-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1420 |
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| Summary: | Aim: To assess simvastatin effectiveness in lipid profile and platelet activity correction among patients with arterial hypertension (AH) and dyslipidemia. Material and methods. In total, 34 patients received simvastatin for 4 months. The dynamics of lipid profile, lipid peroxidation in plasma and platelets, blood and platelet antioxidant protection, and platelet activity was assessed. The statistical methods included Student t-test and correlation analysis. Results. Simvastatin corrected dyslipidemia and lipid peroxidation, as well as optimised intra-platelet mechanisms of platelet function regulation, in AH patients with dyslipidemia. Simvastatin also inhibited increased platelet activation in vitro. Conclusion. Long-term simvastatin therapy resulted in stable positive effects among patients with AH and dyslipidemia. |
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| ISSN: | 1560-4071 2618-7620 |