Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?

Antimicrobial resistance (AR) is recognized as one of the greatest threats to public health and in global concern. Consequently, the increased morbidity and mortality, which are associated with multidrug resistance bacteria, urgently require the discovery of novel and more efficient drugs. Conversel...

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Main Authors: Periyasamy Sivalingam, Kui Hong, John Pote, Kandasamy Prabakar
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:International Journal of Microbiology
Online Access:http://dx.doi.org/10.1155/2019/5283948
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author Periyasamy Sivalingam
Kui Hong
John Pote
Kandasamy Prabakar
author_facet Periyasamy Sivalingam
Kui Hong
John Pote
Kandasamy Prabakar
author_sort Periyasamy Sivalingam
collection DOAJ
description Antimicrobial resistance (AR) is recognized as one of the greatest threats to public health and in global concern. Consequently, the increased morbidity and mortality, which are associated with multidrug resistance bacteria, urgently require the discovery of novel and more efficient drugs. Conversely, cancer is a growing complex human disease that demands new drugs with no or fewer side effects. Most of the drugs currently used in the health care systems were of Streptomyces origin or their synthetic forms. Natural product researches from Streptomyces have been genuinely spectacular over the recent years from extreme environments. It is because of technical advances in isolation, fermentation, spectroscopy, and genomic studies which led to the efficient recovering of Streptomyces and their new chemical compounds with distinct activities. Expanding the use of the last line of antibiotics and demand for new drugs will continue to play an essential role for the potent Streptomyces from previously unexplored environmental sources. In this context, deep-sea, desert, cryo, and volcanic environments have proven to be a unique habitat of more extreme, and of their adaptation to extreme living, environments attribute to novel antibiotics. Extreme Streptomyces have been an excellent source of a new class of compounds which include alkaloids, angucycline, macrolide, and peptides. This review covers novel drug leads with antibacterial and cytotoxic activities isolated from deep-sea, desert, cryo, and volcanic environment Streptomyces from 2009 to 2019. The structure and chemical classes of the compounds, their relevant bioactivities, and the sources of organisms are presented.
format Article
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institution Kabale University
issn 1687-918X
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language English
publishDate 2019-01-01
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series International Journal of Microbiology
spelling doaj-art-cbf879f88b3047cabc1d6637673f57662025-02-03T05:49:21ZengWileyInternational Journal of Microbiology1687-918X1687-91982019-01-01201910.1155/2019/52839485283948Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?Periyasamy Sivalingam0Kui Hong1John Pote2Kandasamy Prabakar3Department F.-A. Forel for Environmental and Aquatic Sciences and Institute of Environmental Sciences, School of Earth and Environmental Sciences, Faculty of Science, University of Geneva, Uni Carl Vogt, 66 Boulevard Carl-Vogt, CH-1211 Geneva 4, SwitzerlandKey Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, ChinaDepartment F.-A. Forel for Environmental and Aquatic Sciences and Institute of Environmental Sciences, School of Earth and Environmental Sciences, Faculty of Science, University of Geneva, Uni Carl Vogt, 66 Boulevard Carl-Vogt, CH-1211 Geneva 4, SwitzerlandPostgraduate and Research Department of Zoology, Jamal Mohamed College, Tiruchirappalli 620020, Tamil Nadu, IndiaAntimicrobial resistance (AR) is recognized as one of the greatest threats to public health and in global concern. Consequently, the increased morbidity and mortality, which are associated with multidrug resistance bacteria, urgently require the discovery of novel and more efficient drugs. Conversely, cancer is a growing complex human disease that demands new drugs with no or fewer side effects. Most of the drugs currently used in the health care systems were of Streptomyces origin or their synthetic forms. Natural product researches from Streptomyces have been genuinely spectacular over the recent years from extreme environments. It is because of technical advances in isolation, fermentation, spectroscopy, and genomic studies which led to the efficient recovering of Streptomyces and their new chemical compounds with distinct activities. Expanding the use of the last line of antibiotics and demand for new drugs will continue to play an essential role for the potent Streptomyces from previously unexplored environmental sources. In this context, deep-sea, desert, cryo, and volcanic environments have proven to be a unique habitat of more extreme, and of their adaptation to extreme living, environments attribute to novel antibiotics. Extreme Streptomyces have been an excellent source of a new class of compounds which include alkaloids, angucycline, macrolide, and peptides. This review covers novel drug leads with antibacterial and cytotoxic activities isolated from deep-sea, desert, cryo, and volcanic environment Streptomyces from 2009 to 2019. The structure and chemical classes of the compounds, their relevant bioactivities, and the sources of organisms are presented.http://dx.doi.org/10.1155/2019/5283948
spellingShingle Periyasamy Sivalingam
Kui Hong
John Pote
Kandasamy Prabakar
Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?
International Journal of Microbiology
title Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?
title_full Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?
title_fullStr Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?
title_full_unstemmed Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?
title_short Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?
title_sort extreme environment streptomyces potential sources for new antibacterial and anticancer drug leads
url http://dx.doi.org/10.1155/2019/5283948
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AT johnpote extremeenvironmentstreptomycespotentialsourcesfornewantibacterialandanticancerdrugleads
AT kandasamyprabakar extremeenvironmentstreptomycespotentialsourcesfornewantibacterialandanticancerdrugleads