The State of the Art of the DSM-5 “with Mixed Features” Specifier

The new DSM-5 “with mixed features” specifier (MFS) has renewed the interest of the scientific community in mixed states, leading not only to new clinical studies but also to new criticisms of the current nosology. Consequently, in our paper we have reviewed the latest literature, trying to understa...

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Main Authors: Norma Verdolini, Mark Agius, Laura Ferranti, Patrizia Moretti, Massimiliano Piselli, Roberto Quartesan
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2015/757258
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author Norma Verdolini
Mark Agius
Laura Ferranti
Patrizia Moretti
Massimiliano Piselli
Roberto Quartesan
author_facet Norma Verdolini
Mark Agius
Laura Ferranti
Patrizia Moretti
Massimiliano Piselli
Roberto Quartesan
author_sort Norma Verdolini
collection DOAJ
description The new DSM-5 “with mixed features” specifier (MFS) has renewed the interest of the scientific community in mixed states, leading not only to new clinical studies but also to new criticisms of the current nosology. Consequently, in our paper we have reviewed the latest literature, trying to understand the reactions of psychiatrists to the new nosology and its epidemiological, prognostic, and clinical consequences. It seems that the most widespread major criticism is the exclusion from the DSM-5 MFS of overlapping symptoms (such as psychomotor agitation, irritability, and distractibility), with a consequent reduction in diagnostic power. On the other hand, undoubtedly the new DSM-5 classification has helped to identify more patients suffering from a mixed state by broadening the narrow DSM-IV-TR criteria. As for the clinical presentation, the epidemiological data, and the therapeutic outcomes, the latest literature does not point out a univocal point of view and further research is needed to fully assess the implications of the new DSM-5 MFS. It is our view that a diagnostic category should be preferred to a specifier and mixed states should be better considered as a spectrum of states, according to what was stated many years ago by Kraepelin.
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spelling doaj-art-cbf5ec5454b04826be86bf0c27be63352025-02-03T01:33:26ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/757258757258The State of the Art of the DSM-5 “with Mixed Features” SpecifierNorma Verdolini0Mark Agius1Laura Ferranti2Patrizia Moretti3Massimiliano Piselli4Roberto Quartesan5School of Specialization in Psychiatry, Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, University of Perugia, Piazzale Lucio Severi 1, Edificio A, 06132 Perugia, ItalyDepartment of Psychiatry, East London Partnership Foundation Trust, Bedfordshire Centre for Mental Health Research in Association with the University of Cambridge, University of Cambridge, Charter House, Alma Street, Luton LU1 2PJ, UKBiotechnologies and Biomaterials in Vascular and Metabolic-Endocrine Diseases, University of Perugia, Piazzale Lucio Severi 1, Edificio A, 06132 Perugia, ItalySanta Maria della Misericordia Hospital, Perugia, ItalyFunctional Area of Psychiatry, University of Perugia, Piazzale Lucio Severi 1, Edificio A, 06132 Perugia, ItalySanta Maria della Misericordia Hospital, Perugia, ItalyThe new DSM-5 “with mixed features” specifier (MFS) has renewed the interest of the scientific community in mixed states, leading not only to new clinical studies but also to new criticisms of the current nosology. Consequently, in our paper we have reviewed the latest literature, trying to understand the reactions of psychiatrists to the new nosology and its epidemiological, prognostic, and clinical consequences. It seems that the most widespread major criticism is the exclusion from the DSM-5 MFS of overlapping symptoms (such as psychomotor agitation, irritability, and distractibility), with a consequent reduction in diagnostic power. On the other hand, undoubtedly the new DSM-5 classification has helped to identify more patients suffering from a mixed state by broadening the narrow DSM-IV-TR criteria. As for the clinical presentation, the epidemiological data, and the therapeutic outcomes, the latest literature does not point out a univocal point of view and further research is needed to fully assess the implications of the new DSM-5 MFS. It is our view that a diagnostic category should be preferred to a specifier and mixed states should be better considered as a spectrum of states, according to what was stated many years ago by Kraepelin.http://dx.doi.org/10.1155/2015/757258
spellingShingle Norma Verdolini
Mark Agius
Laura Ferranti
Patrizia Moretti
Massimiliano Piselli
Roberto Quartesan
The State of the Art of the DSM-5 “with Mixed Features” Specifier
The Scientific World Journal
title The State of the Art of the DSM-5 “with Mixed Features” Specifier
title_full The State of the Art of the DSM-5 “with Mixed Features” Specifier
title_fullStr The State of the Art of the DSM-5 “with Mixed Features” Specifier
title_full_unstemmed The State of the Art of the DSM-5 “with Mixed Features” Specifier
title_short The State of the Art of the DSM-5 “with Mixed Features” Specifier
title_sort state of the art of the dsm 5 with mixed features specifier
url http://dx.doi.org/10.1155/2015/757258
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