Induction of xenobiotic-metabolizing enzymes in hepatocytes by beta-naphthoflavone: Time-dependent changes in activities, protein and mRNA levels

Induction of xenobiotic-metabolizing enzymes in hepatocytes by beta-naphthoflavone: Time-dependent changes in activities, protein and mRNA levels

In the present study, time-dependency of the induction effect of a selective inducer on the activity, protein and mRNA levels of cytochromes P450 1A1/2 (CYP1A1/2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTA), in primary culture of rat hepatocytes was tested and eval...

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Bibliographic Details
Main Authors: Lněničková Kateřina, Skálová Lenka, Stuchlíková Lucie, Szotáková Barbora, Matoušková Petra
Format: Article
Language:English
Published: Sciendo 2018-03-01
Series:Acta Pharmaceutica
Subjects:
aryl hydrocarbon receptor (ahr)
beta-naphthoflavone
rat hepatocyte
time dependency
mrna-protein correlation
Online Access:https://doi.org/10.2478/acph-2018-0005
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https://doi.org/10.2478/acph-2018-0005

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