Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS
Simmental cattle are renowned for their dual purpose as meat and dairy breeds. The study recorded phenotype data from 183 Simmental cattle and performed a Genome-Wide Association Study (GWAS) analysis to elucidate the genetic mechanisms underlying milk production, body size traits, and tail characte...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1491816/full |
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| author | Jie Wang Na Shen Kaisen Zhao Jiayu Liao Genglong Jiang Jianghai Xiao Xianbo Jia Wenqiang Sun Songjia Lai |
| author_facet | Jie Wang Na Shen Kaisen Zhao Jiayu Liao Genglong Jiang Jianghai Xiao Xianbo Jia Wenqiang Sun Songjia Lai |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Simmental cattle are renowned for their dual purpose as meat and dairy breeds. The study recorded phenotype data from 183 Simmental cattle and performed a Genome-Wide Association Study (GWAS) analysis to elucidate the genetic mechanisms underlying milk production, body size traits, and tail characteristics. Statistical analysis of phenotype data showed that season, parity, and age at first calving (AFC) factors had a significant effect on milk production (P < 0.05). The results of GWAS on cattle linear traits revealed that the candidate genes SH3RF2, DCHS2, ADAMTS1, CAMK4, PPARGC1A, PRL, PRP6, and CORIN have been found to affect body circumference (BC) and cannon circumference (CC). Through GWAS analysis of tail traits, including Circumference over tail root (COTR) and Tail Length (TL) in Simmental cattle, candidate genes associated with tail length, such as KIF26B, ITPR2, SLC8A1, and SLIT3 were identified. Interestingly, candidate genes IL1RAP, AQP9, ITPR2, and PKD2 were also associated with metabolic inflammation in cattle tails. These genetic markers offer valuable insights into the traits of Simmental cattle, facilitating the development of molecular breeding strategies to enhance production value and provide references for breeding programs. |
| format | Article |
| id | doaj-art-cbf2b20ffd8b4475afbfae2d4aece97d |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj-art-cbf2b20ffd8b4475afbfae2d4aece97d2025-01-31T06:40:02ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-01-011610.3389/fgene.2025.14918161491816Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWASJie Wang0Na Shen1Kaisen Zhao2Jiayu Liao3Genglong Jiang4Jianghai Xiao5Xianbo Jia6Wenqiang Sun7Songjia Lai8Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, ChinaSimmental cattle are renowned for their dual purpose as meat and dairy breeds. The study recorded phenotype data from 183 Simmental cattle and performed a Genome-Wide Association Study (GWAS) analysis to elucidate the genetic mechanisms underlying milk production, body size traits, and tail characteristics. Statistical analysis of phenotype data showed that season, parity, and age at first calving (AFC) factors had a significant effect on milk production (P < 0.05). The results of GWAS on cattle linear traits revealed that the candidate genes SH3RF2, DCHS2, ADAMTS1, CAMK4, PPARGC1A, PRL, PRP6, and CORIN have been found to affect body circumference (BC) and cannon circumference (CC). Through GWAS analysis of tail traits, including Circumference over tail root (COTR) and Tail Length (TL) in Simmental cattle, candidate genes associated with tail length, such as KIF26B, ITPR2, SLC8A1, and SLIT3 were identified. Interestingly, candidate genes IL1RAP, AQP9, ITPR2, and PKD2 were also associated with metabolic inflammation in cattle tails. These genetic markers offer valuable insights into the traits of Simmental cattle, facilitating the development of molecular breeding strategies to enhance production value and provide references for breeding programs.https://www.frontiersin.org/articles/10.3389/fgene.2025.1491816/fullgenetic analysismilk productionmeat productionphenotypic traitstail length |
| spellingShingle | Jie Wang Na Shen Kaisen Zhao Jiayu Liao Genglong Jiang Jianghai Xiao Xianbo Jia Wenqiang Sun Songjia Lai Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS Frontiers in Genetics genetic analysis milk production meat production phenotypic traits tail length |
| title | Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS |
| title_full | Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS |
| title_fullStr | Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS |
| title_full_unstemmed | Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS |
| title_short | Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS |
| title_sort | revealing study and breeding implications for production traits and tail characteristics in simmental cattle by gwas |
| topic | genetic analysis milk production meat production phenotypic traits tail length |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1491816/full |
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