Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies
Ubiquitination, a multifaceted post-translational modification, regulates protein function, degradation, and gene expression. The pivotal role of ubiquitination in the pathogenesis and progression of cancer, including colorectal, breast, and liver cancer, is well-established. Osteosarcoma, an aggres...
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2024-10-01
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| Series: | Cancer Biology & Medicine |
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| Online Access: | https://www.cancerbiomed.org/content/21/10/880 |
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| author | Jianlin Shen Yue Lai Yanjiao Wu Xuan Lin Cheng Zhang Huan Liu |
| author_facet | Jianlin Shen Yue Lai Yanjiao Wu Xuan Lin Cheng Zhang Huan Liu |
| author_sort | Jianlin Shen |
| collection | DOAJ |
| description | Ubiquitination, a multifaceted post-translational modification, regulates protein function, degradation, and gene expression. The pivotal role of ubiquitination in the pathogenesis and progression of cancer, including colorectal, breast, and liver cancer, is well-established. Osteosarcoma, an aggressive bone tumor predominantly affecting adolescents, also exhibits dysregulation of the ubiquitination system, encompassing both ubiquitination and deubiquitination processes. This dysregulation is now recognized as a key driver of osteosarcoma development, progression, and chemoresistance. This review highlights recent progress in elucidating how ubiquitination modulates tumor behavior across signaling pathways. We then focus on the mechanisms by which ubiquitination influences osteosarcoma cell function. Finally, we discuss the potential for targeting the ubiquitin-proteasome system in osteosarcoma therapy. By unraveling the impact of ubiquitination on osteosarcoma cell physiology, we aim to facilitate the development of novel strategies for prognosis, staging, treatment, and overcoming chemoresistance. |
| format | Article |
| id | doaj-art-cbf0bace82fc46d98678ad1f052d2a31 |
| institution | OA Journals |
| issn | 2095-3941 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj-art-cbf0bace82fc46d98678ad1f052d2a312025-08-20T01:47:26ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412024-10-01211088089710.20892/j.issn.2095-3941.2024.0231Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategiesJianlin Shen0Yue Lai1Yanjiao Wu2Xuan Lin3Cheng Zhang4Huan Liu5Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, ChinaDepartment of Orthopedics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaShunde Hospital, Southern Medical University (The First People’s Hospital of Shunde), Foshan 528000, ChinaDepartment of Environmental and Biological Engineering, Putian University, Putian 351100, ChinaDepartment of Trauma Center, Zhongda Hospital, Southeast University, Nanjing 210000, ChinaDepartment of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, ChinaUbiquitination, a multifaceted post-translational modification, regulates protein function, degradation, and gene expression. The pivotal role of ubiquitination in the pathogenesis and progression of cancer, including colorectal, breast, and liver cancer, is well-established. Osteosarcoma, an aggressive bone tumor predominantly affecting adolescents, also exhibits dysregulation of the ubiquitination system, encompassing both ubiquitination and deubiquitination processes. This dysregulation is now recognized as a key driver of osteosarcoma development, progression, and chemoresistance. This review highlights recent progress in elucidating how ubiquitination modulates tumor behavior across signaling pathways. We then focus on the mechanisms by which ubiquitination influences osteosarcoma cell function. Finally, we discuss the potential for targeting the ubiquitin-proteasome system in osteosarcoma therapy. By unraveling the impact of ubiquitination on osteosarcoma cell physiology, we aim to facilitate the development of novel strategies for prognosis, staging, treatment, and overcoming chemoresistance.https://www.cancerbiomed.org/content/21/10/880ubiquitinationosteosarcomacancer developmenttherapeutic target |
| spellingShingle | Jianlin Shen Yue Lai Yanjiao Wu Xuan Lin Cheng Zhang Huan Liu Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies Cancer Biology & Medicine ubiquitination osteosarcoma cancer development therapeutic target |
| title | Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies |
| title_full | Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies |
| title_fullStr | Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies |
| title_full_unstemmed | Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies |
| title_short | Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies |
| title_sort | ubiquitination in osteosarcoma unveiling the impact on cell biology and therapeutic strategies |
| topic | ubiquitination osteosarcoma cancer development therapeutic target |
| url | https://www.cancerbiomed.org/content/21/10/880 |
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