LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review
Abstract Metabolism reprogramming (MR) is one of the top ten hallmarks of malignant tumors. The aberrant activation of MR has been recognized as a critical contributory factor to the malignant progression of solid tumors. Moreover, various long non-coding RNAs (lncRNAs) are implicated in the aberran...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-024-00866-0 |
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| author | Kun Fang Huizhe Xu Shuai Yuan Xiaoxi Li Xiaoyu Chen Xiushi Fan Xiaoxin Gao Lu Zhang Shulan Sun Xudong Zhu |
| author_facet | Kun Fang Huizhe Xu Shuai Yuan Xiaoxi Li Xiaoyu Chen Xiushi Fan Xiaoxin Gao Lu Zhang Shulan Sun Xudong Zhu |
| author_sort | Kun Fang |
| collection | DOAJ |
| description | Abstract Metabolism reprogramming (MR) is one of the top ten hallmarks of malignant tumors. The aberrant activation of MR has been recognized as a critical contributory factor to the malignant progression of solid tumors. Moreover, various long non-coding RNAs (lncRNAs) are implicated in the aberrant activation of MR in solid tumor cells. Therefore, in this review, we mainly focus on summarizing the functional relevance and molecular mechanistic underpinnings of lncRNAs in modulating MR of solid tumors by targeting glucose metabolism, lipid metabolism, affecting mitochondrial function, and regulating interactions between tumor and non-tumor cells in tumor microenvironment. Besides, we also underscore the potential for constructing lncRNAs-centered tumor metabolic regulation networks and developing novel anti-tumor strategies by targeting lncRNAs and abnormal MR. Ultimately, this review seeks to offer new targets and avenues for the clinical treatment of solid tumors in the future. |
| format | Article |
| id | doaj-art-cbd9ac043ef2425896d4bcfb865eeeb3 |
| institution | DOAJ |
| issn | 1743-7075 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj-art-cbd9ac043ef2425896d4bcfb865eeeb32025-08-20T02:49:56ZengBMCNutrition & Metabolism1743-70752024-11-0121111310.1186/s12986-024-00866-0LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update reviewKun Fang0Huizhe Xu1Shuai Yuan2Xiaoxi Li3Xiaoyu Chen4Xiushi Fan5Xiaoxin Gao6Lu Zhang7Shulan Sun8Xudong Zhu9Central Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteCentral Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteCentral Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteCentral Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteCentral Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteCentral Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteCentral Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteDepartment of Human Resources, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteCentral Laboratory, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteDepartment of General Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteAbstract Metabolism reprogramming (MR) is one of the top ten hallmarks of malignant tumors. The aberrant activation of MR has been recognized as a critical contributory factor to the malignant progression of solid tumors. Moreover, various long non-coding RNAs (lncRNAs) are implicated in the aberrant activation of MR in solid tumor cells. Therefore, in this review, we mainly focus on summarizing the functional relevance and molecular mechanistic underpinnings of lncRNAs in modulating MR of solid tumors by targeting glucose metabolism, lipid metabolism, affecting mitochondrial function, and regulating interactions between tumor and non-tumor cells in tumor microenvironment. Besides, we also underscore the potential for constructing lncRNAs-centered tumor metabolic regulation networks and developing novel anti-tumor strategies by targeting lncRNAs and abnormal MR. Ultimately, this review seeks to offer new targets and avenues for the clinical treatment of solid tumors in the future.https://doi.org/10.1186/s12986-024-00866-0Long non-coding RNAMetabolic reprogrammingSolid tumorsTherapeutic targets |
| spellingShingle | Kun Fang Huizhe Xu Shuai Yuan Xiaoxi Li Xiaoyu Chen Xiushi Fan Xiaoxin Gao Lu Zhang Shulan Sun Xudong Zhu LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review Nutrition & Metabolism Long non-coding RNA Metabolic reprogramming Solid tumors Therapeutic targets |
| title | LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review |
| title_full | LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review |
| title_fullStr | LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review |
| title_full_unstemmed | LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review |
| title_short | LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review |
| title_sort | lncrna mediated metabolic reprogramming the chief culprits of solid tumor malignant progression an update review |
| topic | Long non-coding RNA Metabolic reprogramming Solid tumors Therapeutic targets |
| url | https://doi.org/10.1186/s12986-024-00866-0 |
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