Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine

Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine

Agomelatine (AGM) is an effective antidepressant with low oral bioavailability due to intensive hepatic metabolism. Transdermal administration of agomelatine may increase its bioavailability and reduce the doses necessary for therapeutic effects. However, transdermal delivery requires crossing the &...

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Main Authors: Monika Wojtyłko, Ariadna B. Nowicka, Anna Froelich, Mirosław Szybowicz, Tobiasz Banaszek, Dorota Tomczak, Wiesław Kuczko, Radosław Wichniarek, Irena Budnik, Barbara Jadach, Oliwia Kordyl, Antoni Białek, Julia Krysztofiak, Tomasz Osmałek, Dimitrios A. Lamprou
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
agomelatine
transdermal delivery
hydrogel
coated microneedles
Online Access:https://www.mdpi.com/1420-3049/30/2/322
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