The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study
Background. The increased prevalence of glycolipid metabolism disorders (GLMD) in childhood and adolescents has a well-established association with adult type 2 diabetes and cardiovascular diseases; therefore, determinants of GLMD need to be evaluated during this period. Objectives. To explore the p...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/6214785 |
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| author | Xiao-Hua Liang Lun Xiao Jing-Yu Chen Ping Qu Xian Tang Yuwei Wang |
| author_facet | Xiao-Hua Liang Lun Xiao Jing-Yu Chen Ping Qu Xian Tang Yuwei Wang |
| author_sort | Xiao-Hua Liang |
| collection | DOAJ |
| description | Background. The increased prevalence of glycolipid metabolism disorders (GLMD) in childhood and adolescents has a well-established association with adult type 2 diabetes and cardiovascular diseases; therefore, determinants of GLMD need to be evaluated during this period. Objectives. To explore the prevalence of and risk factors for GLMD from the prenatal period through childhood and adolescence. Methods. A bidirectional cohort study which was established in 2014 and followed between March 1 and July 20, 2019, was used to illustrate the impact factors for GLMD. Stratified cluster sampling in urban-rural areas was used to include subjects from four communities in Chongqing. 2808 healthy children aged between 6 and 9 years in 2014 entered the cohort in 2014 and followed in 2019 with a follow-up rate of 70%. 2,136 samples (aged 11.68 ± 0.60 years) were included. Results. The prevalence rates of insulin resistance (IR), prediabetes/diabetes, and dyslipidemia were 21.02%, 7.19%, and 21.61%, respectively. Subjects with an urban residence, no pubertal development, dyslipidemia in 2014, higher family income, and higher parental education had significantly elevated fasting insulin (FI) or homeostasis model assessment of insulin resistance (HOMA-IR) levels; subjects with female sex, no pubertal development, dyslipidemia in 2014, obesity, gestational hypertension, maternal weight gain above Institute of Medicine guidelines, and single parents had increased triglyceride or triglyceride/high-density lipoprotein (HDL). Adolescents with rural residence had higher HbA1c level. Conclusion. We observed that the prevalence of GLMD was high in childhood and adolescents, and rural-urban areas, sex, pubertal development, dyslipidemia in a younger age, maternal obesity, and hypertension were associated with increased GLMD risk, suggesting that implementing the community-family intervention to improve the GLMD of children is essential. |
| format | Article |
| id | doaj-art-cbc1182df9644bb2937bd85f81f16d1c |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-cbc1182df9644bb2937bd85f81f16d1c2025-02-03T01:07:21ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/6214785The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort StudyXiao-Hua Liang0Lun Xiao1Jing-Yu Chen2Ping Qu3Xian Tang4Yuwei Wang5Clinical Epidemiology and Biostatistics Department of Children’s Hospital of Chongqing Medical UniversityCenters for Disease Control and Prevention of Jiulongpo DistrictUltrasound Department of Children’s Hospital of Chongqing Medical UniversityClinical Epidemiology and Biostatistics Department of Children’s Hospital of Chongqing Medical UniversityClinical Epidemiology and Biostatistics Department of Children’s Hospital of Chongqing Medical UniversityDepartment of Laboratory MedicineBackground. The increased prevalence of glycolipid metabolism disorders (GLMD) in childhood and adolescents has a well-established association with adult type 2 diabetes and cardiovascular diseases; therefore, determinants of GLMD need to be evaluated during this period. Objectives. To explore the prevalence of and risk factors for GLMD from the prenatal period through childhood and adolescence. Methods. A bidirectional cohort study which was established in 2014 and followed between March 1 and July 20, 2019, was used to illustrate the impact factors for GLMD. Stratified cluster sampling in urban-rural areas was used to include subjects from four communities in Chongqing. 2808 healthy children aged between 6 and 9 years in 2014 entered the cohort in 2014 and followed in 2019 with a follow-up rate of 70%. 2,136 samples (aged 11.68 ± 0.60 years) were included. Results. The prevalence rates of insulin resistance (IR), prediabetes/diabetes, and dyslipidemia were 21.02%, 7.19%, and 21.61%, respectively. Subjects with an urban residence, no pubertal development, dyslipidemia in 2014, higher family income, and higher parental education had significantly elevated fasting insulin (FI) or homeostasis model assessment of insulin resistance (HOMA-IR) levels; subjects with female sex, no pubertal development, dyslipidemia in 2014, obesity, gestational hypertension, maternal weight gain above Institute of Medicine guidelines, and single parents had increased triglyceride or triglyceride/high-density lipoprotein (HDL). Adolescents with rural residence had higher HbA1c level. Conclusion. We observed that the prevalence of GLMD was high in childhood and adolescents, and rural-urban areas, sex, pubertal development, dyslipidemia in a younger age, maternal obesity, and hypertension were associated with increased GLMD risk, suggesting that implementing the community-family intervention to improve the GLMD of children is essential.http://dx.doi.org/10.1155/2022/6214785 |
| spellingShingle | Xiao-Hua Liang Lun Xiao Jing-Yu Chen Ping Qu Xian Tang Yuwei Wang The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study International Journal of Endocrinology |
| title | The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study |
| title_full | The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study |
| title_fullStr | The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study |
| title_full_unstemmed | The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study |
| title_short | The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study |
| title_sort | determinants of adolescent glycolipid metabolism disorder a cohort study |
| url | http://dx.doi.org/10.1155/2022/6214785 |
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