Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature
Human immune deficiency virus- (HIV-) infected individuals present a higher risk of developing malignancies. Herein, we are presenting an unusual case of an untreated HIV+ patient, who developed two distinct lymphoproliferative disorders in a period of 4 years: a primary cutaneous T-cell lymphoma (P...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/8959145 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560347651768320 |
|---|---|
| author | Clara Bertuzzi Elena Sabattini Francesco Bacci Claudio Agostinelli Gian Gaetano Ferri |
| author_facet | Clara Bertuzzi Elena Sabattini Francesco Bacci Claudio Agostinelli Gian Gaetano Ferri |
| author_sort | Clara Bertuzzi |
| collection | DOAJ |
| description | Human immune deficiency virus- (HIV-) infected individuals present a higher risk of developing malignancies. Herein, we are presenting an unusual case of an untreated HIV+ patient, who developed two distinct lymphoproliferative disorders in a period of 4 years: a primary cutaneous T-cell lymphoma (PCTCL) and a diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), the latter developed while commencing combined antiretroviral therapy (cART). The two lymphomas also showed peculiar features: PCTCL are rarely described in HIV+ setting and particularly at such a low clinical stage, and the DLBCL showed uncommon cytology, non-GCB phenotype, EBER negativity, and absence of c-MYC translocation, all atypical features in this clinical context. This report not only confirms the increased risk of lymphoma for HIV+ patients and HIV infection being one of the major risk factors for lymphoid disorders but draws the attention on the possible occurrence of unusual features, suggesting that HIV serology should always be investigated in the clinical suspicion of lymphoma. |
| format | Article |
| id | doaj-art-cbbd32af5f29441d9af56faf9645a4b1 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-cbbd32af5f29441d9af56faf9645a4b12025-02-03T01:27:54ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/89591458959145Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the LiteratureClara Bertuzzi0Elena Sabattini1Francesco Bacci2Claudio Agostinelli3Gian Gaetano Ferri4Hematopathology Unit, Sant’Orsola University Hospital, Bologna, ItalyHematopathology Unit, Sant’Orsola University Hospital, Bologna, ItalyHematopathology Unit, Sant’Orsola University Hospital, Bologna, ItalyHematopathology Unit, Sant’Orsola University Hospital, Bologna, ItalyENT and Audiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, Sant’ Orsola Hospital, University of Bologna, Bologna, ItalyHuman immune deficiency virus- (HIV-) infected individuals present a higher risk of developing malignancies. Herein, we are presenting an unusual case of an untreated HIV+ patient, who developed two distinct lymphoproliferative disorders in a period of 4 years: a primary cutaneous T-cell lymphoma (PCTCL) and a diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), the latter developed while commencing combined antiretroviral therapy (cART). The two lymphomas also showed peculiar features: PCTCL are rarely described in HIV+ setting and particularly at such a low clinical stage, and the DLBCL showed uncommon cytology, non-GCB phenotype, EBER negativity, and absence of c-MYC translocation, all atypical features in this clinical context. This report not only confirms the increased risk of lymphoma for HIV+ patients and HIV infection being one of the major risk factors for lymphoid disorders but draws the attention on the possible occurrence of unusual features, suggesting that HIV serology should always be investigated in the clinical suspicion of lymphoma.http://dx.doi.org/10.1155/2019/8959145 |
| spellingShingle | Clara Bertuzzi Elena Sabattini Francesco Bacci Claudio Agostinelli Gian Gaetano Ferri Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature Case Reports in Hematology |
| title | Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature |
| title_full | Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature |
| title_fullStr | Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature |
| title_full_unstemmed | Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature |
| title_short | Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature |
| title_sort | two different extranodal lymphomas in an hiv patient a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2019/8959145 |
| work_keys_str_mv | AT clarabertuzzi twodifferentextranodallymphomasinanhivpatientacasereportandreviewoftheliterature AT elenasabattini twodifferentextranodallymphomasinanhivpatientacasereportandreviewoftheliterature AT francescobacci twodifferentextranodallymphomasinanhivpatientacasereportandreviewoftheliterature AT claudioagostinelli twodifferentextranodallymphomasinanhivpatientacasereportandreviewoftheliterature AT giangaetanoferri twodifferentextranodallymphomasinanhivpatientacasereportandreviewoftheliterature |