Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever.

Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever.

Lassa fever is a highly lethal hemorrhagic fever endemic to West Africa. In the absence of efficient prophylactic or therapeutic countermeasures, it poses a substantial threat to public health in this region. The pathophysiological mechanisms underlying the severity of the disease are poorly known b...

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Main Authors: Blaise Lafoux, Gustave Fourcaud, Jimmy Hortion, Laura Soyer, Alexandra Journeaux, Clara Germain, Stéphanie Reynard, Hadrien Cousseau, Clémentine Larignon, Natalia Pietrosemoli, Séverine Croze, Joël Lachuer, Emeline Perthame, Sylvain Baize
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013111
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