Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering
Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitatio...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/685690 |
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| author | Yuting Li Hao Meng Yuan Liu Bruce P. Lee |
| author_facet | Yuting Li Hao Meng Yuan Liu Bruce P. Lee |
| author_sort | Yuting Li |
| collection | DOAJ |
| description | Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural blood-clotting process and self-assembles into a polymer network. The ability for fibrin to cure in situ has been exploited to develop injectable scaffolds for the repair of damaged cardiac and cartilage tissues. Additionally, fibrin gel has been utilized as a cell carrier to protect cells from the forces during the application and cell delivery processes while enhancing the cell viability and tissue regeneration. Here, we review the recent advancement in developing fibrin-based biomaterials for the development of injectable tissue engineering scaffold and cell carriers. |
| format | Article |
| id | doaj-art-cbac92471f3f46658d5920df667e9107 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cbac92471f3f46658d5920df667e91072025-02-03T01:23:22ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/685690685690Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue EngineeringYuting Li0Hao Meng1Yuan Liu2Bruce P. Lee3Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USADepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USADepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USADepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USADue to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural blood-clotting process and self-assembles into a polymer network. The ability for fibrin to cure in situ has been exploited to develop injectable scaffolds for the repair of damaged cardiac and cartilage tissues. Additionally, fibrin gel has been utilized as a cell carrier to protect cells from the forces during the application and cell delivery processes while enhancing the cell viability and tissue regeneration. Here, we review the recent advancement in developing fibrin-based biomaterials for the development of injectable tissue engineering scaffold and cell carriers.http://dx.doi.org/10.1155/2015/685690 |
| spellingShingle | Yuting Li Hao Meng Yuan Liu Bruce P. Lee Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering The Scientific World Journal |
| title | Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering |
| title_full | Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering |
| title_fullStr | Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering |
| title_full_unstemmed | Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering |
| title_short | Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering |
| title_sort | fibrin gel as an injectable biodegradable scaffold and cell carrier for tissue engineering |
| url | http://dx.doi.org/10.1155/2015/685690 |
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