Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential
Advancements in assisted reproductive technologies (ARTs) have led to the development of various add-on techniques aimed at improving oocyte quality and enhancing embryo implantation potential. These techniques target critical stages of both oocyte and embryo physiology, including oocyte growth and...
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MDPI AG
2025-02-01
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| author | Nikos Petrogiannis Maria Filippa Kalliopi Chatzovoulou Savvas Petrogiannis Ioannis Filippas Grigoris Grimbizis Efstratios Kolibianakis Katerina Chatzimeletiou |
| author_facet | Nikos Petrogiannis Maria Filippa Kalliopi Chatzovoulou Savvas Petrogiannis Ioannis Filippas Grigoris Grimbizis Efstratios Kolibianakis Katerina Chatzimeletiou |
| author_sort | Nikos Petrogiannis |
| collection | DOAJ |
| description | Advancements in assisted reproductive technologies (ARTs) have led to the development of various add-on techniques aimed at improving oocyte quality and enhancing embryo implantation potential. These techniques target critical stages of both oocyte and embryo physiology, including oocyte growth and maturation, fertilization, chromosomal status, and embryo development. Key approaches involve the optimization of in vitro fertilization (IVF) protocols, recruiting capable follicles giving rise to dynamic oocytes to evolve, culture media supplementation, preimplantation genetic testing (PGT), and mitochondrial replacement therapy (MRT), all of which are designed to enhance oocyte competence through its function and metabolism. The use of PGT has been promising in selecting embryos suitable for transfer, thus optimizing implantation success. Emerging technologies, such as platelet-rich plasma treatment (PRP), time-lapse imaging (TLI), and hyaluronan-rich (HA) culture media, claim to improve ovarian rejuvenation and uterine receptivity, embryo selection, as well as embryo implantation potential, respectively. Evidence for certain add-on approaches remains limited, but ongoing research suggests that the use of such treatments may lead to increased clinical pregnancies and live birth rates, especially in poor-prognosis patients. The present review describes the current state of the add-on innovations, their mechanisms of action, as well as their possibilities to increase ART success rates. |
| format | Article |
| id | doaj-art-cbabcffaee054236b6973d3a149fdc8a |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-cbabcffaee054236b6973d3a149fdc8a2025-08-20T02:42:26ZengMDPI AGMedicina1010-660X1648-91442025-02-0161336710.3390/medicina61030367Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation PotentialNikos Petrogiannis0Maria Filippa1Kalliopi Chatzovoulou2Savvas Petrogiannis3Ioannis Filippas4Grigoris Grimbizis5Efstratios Kolibianakis6Katerina Chatzimeletiou7ART Unit, Naval Hospital of Athens, 11521 Athens, GreeceART Unit, Naval Hospital of Athens, 11521 Athens, GreeceART Unit, Naval Hospital of Athens, 11521 Athens, GreeceART Unit, Naval Hospital of Athens, 11521 Athens, GreeceART Unit, Naval Hospital of Athens, 11521 Athens, GreeceUnit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceAdvancements in assisted reproductive technologies (ARTs) have led to the development of various add-on techniques aimed at improving oocyte quality and enhancing embryo implantation potential. These techniques target critical stages of both oocyte and embryo physiology, including oocyte growth and maturation, fertilization, chromosomal status, and embryo development. Key approaches involve the optimization of in vitro fertilization (IVF) protocols, recruiting capable follicles giving rise to dynamic oocytes to evolve, culture media supplementation, preimplantation genetic testing (PGT), and mitochondrial replacement therapy (MRT), all of which are designed to enhance oocyte competence through its function and metabolism. The use of PGT has been promising in selecting embryos suitable for transfer, thus optimizing implantation success. Emerging technologies, such as platelet-rich plasma treatment (PRP), time-lapse imaging (TLI), and hyaluronan-rich (HA) culture media, claim to improve ovarian rejuvenation and uterine receptivity, embryo selection, as well as embryo implantation potential, respectively. Evidence for certain add-on approaches remains limited, but ongoing research suggests that the use of such treatments may lead to increased clinical pregnancies and live birth rates, especially in poor-prognosis patients. The present review describes the current state of the add-on innovations, their mechanisms of action, as well as their possibilities to increase ART success rates.https://www.mdpi.com/1648-9144/61/3/367platelet-rich plasmain vitro maturationartificial oocyte activationpreimplantation genetic testingtime-lapse imagingmitochondrial replacement therapy |
| spellingShingle | Nikos Petrogiannis Maria Filippa Kalliopi Chatzovoulou Savvas Petrogiannis Ioannis Filippas Grigoris Grimbizis Efstratios Kolibianakis Katerina Chatzimeletiou Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential Medicina platelet-rich plasma in vitro maturation artificial oocyte activation preimplantation genetic testing time-lapse imaging mitochondrial replacement therapy |
| title | Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential |
| title_full | Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential |
| title_fullStr | Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential |
| title_full_unstemmed | Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential |
| title_short | Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential |
| title_sort | add on technologies that aim to improve oocyte quality and embryo implantation potential |
| topic | platelet-rich plasma in vitro maturation artificial oocyte activation preimplantation genetic testing time-lapse imaging mitochondrial replacement therapy |
| url | https://www.mdpi.com/1648-9144/61/3/367 |
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