Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer
Aim. The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC). As part of the renin-angiotensin system (RAS) whose activity is known...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/6845213 |
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| author | Katrin Kreienbring Annika Franz Rolf Richter Duska Dragun Harald Heidecke Ralf Dechend Dominik N. Muller Jalid Sehouli Elena I. Braicu |
| author_facet | Katrin Kreienbring Annika Franz Rolf Richter Duska Dragun Harald Heidecke Ralf Dechend Dominik N. Muller Jalid Sehouli Elena I. Braicu |
| author_sort | Katrin Kreienbring |
| collection | DOAJ |
| description | Aim. The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC). As part of the renin-angiotensin system (RAS) whose activity is known to increase in ovarian cancer patients, the relation of sPRR and ovarian cancer should be further investigated. Patients and Methods. In this study 197 patients with primary EOC in our institution from 2000 to 2011 were included. sPRR was determined by enzyme-linked immunosorbent assay (ELISA) in preoperative taken blood sera. Associations with clinicopathological outcome were analyzed and serum levels of sPRR in patients have been compared to those in healthy specimen. Kaplan-Meier and logistic/Cox regression assessed the impact of the markers on progression-free survival (PFS) and overall survival (OS). Results. There have been no correlations proved of sPRR levels with neither clinicopathological factors nor prognostic data. Also the distribution of sPRR in patients and controls was normal. Conclusion. sPRR seems to have no predictive, prognostic, or diagnostic value in EOC. As several factors of the RAS which might indicate cancer events have been shown, sPRR seems not to be affected. |
| format | Article |
| id | doaj-art-cba8ea3e81074fa69e0fa0cea05d0f43 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-cba8ea3e81074fa69e0fa0cea05d0f432025-02-03T06:06:39ZengWileyAnalytical Cellular Pathology2210-71772210-71852016-01-01201610.1155/2016/68452136845213Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian CancerKatrin Kreienbring0Annika Franz1Rolf Richter2Duska Dragun3Harald Heidecke4Ralf Dechend5Dominik N. Muller6Jalid Sehouli7Elena I. Braicu8Department of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, GermanyDepartment of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, GermanyDepartment of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, GermanyDepartment of Nephrology and Intensive Care Medicine, Charité Universtätsmedizin Berlin, Berlin, GermanyCellTrend, Luckenwalde, GermanyExperimental and Clinical Research Center, Berlin, GermanyExperimental and Clinical Research Center, Berlin, GermanyDepartment of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, GermanyDepartment of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, GermanyAim. The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC). As part of the renin-angiotensin system (RAS) whose activity is known to increase in ovarian cancer patients, the relation of sPRR and ovarian cancer should be further investigated. Patients and Methods. In this study 197 patients with primary EOC in our institution from 2000 to 2011 were included. sPRR was determined by enzyme-linked immunosorbent assay (ELISA) in preoperative taken blood sera. Associations with clinicopathological outcome were analyzed and serum levels of sPRR in patients have been compared to those in healthy specimen. Kaplan-Meier and logistic/Cox regression assessed the impact of the markers on progression-free survival (PFS) and overall survival (OS). Results. There have been no correlations proved of sPRR levels with neither clinicopathological factors nor prognostic data. Also the distribution of sPRR in patients and controls was normal. Conclusion. sPRR seems to have no predictive, prognostic, or diagnostic value in EOC. As several factors of the RAS which might indicate cancer events have been shown, sPRR seems not to be affected.http://dx.doi.org/10.1155/2016/6845213 |
| spellingShingle | Katrin Kreienbring Annika Franz Rolf Richter Duska Dragun Harald Heidecke Ralf Dechend Dominik N. Muller Jalid Sehouli Elena I. Braicu Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer Analytical Cellular Pathology |
| title | Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer |
| title_full | Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer |
| title_fullStr | Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer |
| title_full_unstemmed | Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer |
| title_short | Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer |
| title_sort | predictive and prognostic value of sprr in patients with primary epithelial ovarian cancer |
| url | http://dx.doi.org/10.1155/2016/6845213 |
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