Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis
Background. Ulcerative colitis (UC) patients have an increased risk for the development of colorectal cancer (CRC). Our aim was to assess the risk of CRC in UC patients compared with disease extent, disease duration, and geographic variation. Methods. In this systematic review and meta-analysis, we...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/5363261 |
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| author | Qing Zhou Zhao-Feng Shen Ben-sheng Wu Cheng-biao Xu Zhong-qi He Tuo Chen Hong-tao Shang Chao-fan Xie Si-yi Huang Yu-gen Chen Hai-bo Chen Shu-tang Han |
| author_facet | Qing Zhou Zhao-Feng Shen Ben-sheng Wu Cheng-biao Xu Zhong-qi He Tuo Chen Hong-tao Shang Chao-fan Xie Si-yi Huang Yu-gen Chen Hai-bo Chen Shu-tang Han |
| author_sort | Qing Zhou |
| collection | DOAJ |
| description | Background. Ulcerative colitis (UC) patients have an increased risk for the development of colorectal cancer (CRC). Our aim was to assess the risk of CRC in UC patients compared with disease extent, disease duration, and geographic variation. Methods. In this systematic review and meta-analysis, we searched PubMed, scientific meetings, and the bibliographies of identified articles, with English language restrictions for studies published from 1988 to 2018, and assessed the risk of CRC in UC patients. Patients with Crohn’s disease, family history of CRC, and colorectal adenomatous polyp (CAP) were excluded from this research. The study was registered with PROSPERO, number CRD42018102213. Findings. We included 58 studies that included 267566 UC patients. Extensive UC and left-sided UC had a higher risk of CRC than proctitis UC. Geography also played a role in UC-associated CRC development. The time of malignant transformation in Asian UC patients started after 10-20 years of this disease duration. North American UC-associated CRC patients significantly increased in more than 30 years of this disease duration. Conclusion. In a systematic review of the literature, we found that disease extent, disease duration, and geography were strong, independent risk factors in UC-associated CRC development. |
| format | Article |
| id | doaj-art-cb9bdf7248514adf9a9ae742ca07f90e |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-cb9bdf7248514adf9a9ae742ca07f90e2025-02-03T01:06:41ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/53632615363261Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-AnalysisQing Zhou0Zhao-Feng Shen1Ben-sheng Wu2Cheng-biao Xu3Zhong-qi He4Tuo Chen5Hong-tao Shang6Chao-fan Xie7Si-yi Huang8Yu-gen Chen9Hai-bo Chen10Shu-tang Han11Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaSuzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, ChinaXuyi Hospital of Traditional Chinese Medicine, Huaian, Jiangsu, ChinaSuzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, ChinaNanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaShishi General Hospital, Quanzhou, Fujian, ChinaThe First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, ChinaAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaNanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaBackground. Ulcerative colitis (UC) patients have an increased risk for the development of colorectal cancer (CRC). Our aim was to assess the risk of CRC in UC patients compared with disease extent, disease duration, and geographic variation. Methods. In this systematic review and meta-analysis, we searched PubMed, scientific meetings, and the bibliographies of identified articles, with English language restrictions for studies published from 1988 to 2018, and assessed the risk of CRC in UC patients. Patients with Crohn’s disease, family history of CRC, and colorectal adenomatous polyp (CAP) were excluded from this research. The study was registered with PROSPERO, number CRD42018102213. Findings. We included 58 studies that included 267566 UC patients. Extensive UC and left-sided UC had a higher risk of CRC than proctitis UC. Geography also played a role in UC-associated CRC development. The time of malignant transformation in Asian UC patients started after 10-20 years of this disease duration. North American UC-associated CRC patients significantly increased in more than 30 years of this disease duration. Conclusion. In a systematic review of the literature, we found that disease extent, disease duration, and geography were strong, independent risk factors in UC-associated CRC development.http://dx.doi.org/10.1155/2019/5363261 |
| spellingShingle | Qing Zhou Zhao-Feng Shen Ben-sheng Wu Cheng-biao Xu Zhong-qi He Tuo Chen Hong-tao Shang Chao-fan Xie Si-yi Huang Yu-gen Chen Hai-bo Chen Shu-tang Han Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis |
| title_full | Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis |
| title_short | Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis |
| title_sort | risk of colorectal cancer in ulcerative colitis patients a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2019/5363261 |
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