Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults
Background and Aims. High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/709024 |
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| _version_ | 1832545604669014016 |
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| author | Shih-Ping Cheng Chien-Liang Liu Tsang-Pai Liu Yi-Chiung Hsu Jie-Jen Lee |
| author_facet | Shih-Ping Cheng Chien-Liang Liu Tsang-Pai Liu Yi-Chiung Hsu Jie-Jen Lee |
| author_sort | Shih-Ping Cheng |
| collection | DOAJ |
| description | Background and Aims. High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults. Materials and Methods. Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein (CRP), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) levels with weighted linear regression. Additionally, we examined the relation with increased modified Glasgow Prognostic Score (mGPS) by using weighted logistic regression. Results. CRP, RDW, and PLR values increased with increasing serum PTH concentration. After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories (all P<0.001), while PLR marginally increased (P=0.190 and P=0.095 using PTH as a categorical and continuous variable, resp.). The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously. Conclusion. These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population. The casual relationship between PTH levels and inflammation remains to be elucidated. |
| format | Article |
| id | doaj-art-cb99ddd70ba44578b574f2948c120358 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cb99ddd70ba44578b574f2948c1203582025-02-03T07:25:17ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/709024709024Association between Parathyroid Hormone Levels and Inflammatory Markers among US AdultsShih-Ping Cheng0Chien-Liang Liu1Tsang-Pai Liu2Yi-Chiung Hsu3Jie-Jen Lee4Department of Surgery, Mackay Memorial Hospital and Mackay Medical College, 92 Chung-Shan North Road, Section 2, Taipei 10449, TaiwanDepartment of Surgery, Mackay Memorial Hospital and Mackay Medical College, 92 Chung-Shan North Road, Section 2, Taipei 10449, TaiwanDepartment of Surgery, Mackay Memorial Hospital and Mackay Medical College, 92 Chung-Shan North Road, Section 2, Taipei 10449, TaiwanInstitute of Statistical Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, TaiwanDepartment of Surgery, Mackay Memorial Hospital and Mackay Medical College, 92 Chung-Shan North Road, Section 2, Taipei 10449, TaiwanBackground and Aims. High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults. Materials and Methods. Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein (CRP), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) levels with weighted linear regression. Additionally, we examined the relation with increased modified Glasgow Prognostic Score (mGPS) by using weighted logistic regression. Results. CRP, RDW, and PLR values increased with increasing serum PTH concentration. After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories (all P<0.001), while PLR marginally increased (P=0.190 and P=0.095 using PTH as a categorical and continuous variable, resp.). The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously. Conclusion. These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population. The casual relationship between PTH levels and inflammation remains to be elucidated.http://dx.doi.org/10.1155/2014/709024 |
| spellingShingle | Shih-Ping Cheng Chien-Liang Liu Tsang-Pai Liu Yi-Chiung Hsu Jie-Jen Lee Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults Mediators of Inflammation |
| title | Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults |
| title_full | Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults |
| title_fullStr | Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults |
| title_full_unstemmed | Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults |
| title_short | Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults |
| title_sort | association between parathyroid hormone levels and inflammatory markers among us adults |
| url | http://dx.doi.org/10.1155/2014/709024 |
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