Evaluation of the Safety and Efficacy of N-acetylcysteine in the Prevention of Paclitaxel-induced Peripheral Neuropathy: A Randomized, Double-blind, and Placebo-controlled Trial

Evaluation of the Safety and Efficacy of N-acetylcysteine in the Prevention of Paclitaxel-induced Peripheral Neuropathy: A Randomized, Double-blind, and Placebo-controlled Trial

Objective: Paclitaxel-induced peripheral neuropathy (PIPN) is a disabling condition that leads to discontinuation or dose reduction of chemotherapy and reduces the patient’s quality of life (QOL). We investigated the effect of N-acetylcysteine (NAC) in preventing PIPN. Methods: This study was a rand...

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Main Authors: Sima Ramezaninejad, Ehsan Zaboli, Mohammad Eslamijouybari, Leila Mirzakhani, Fatemeh Shaki, Mahmood Moosazadeh, Hamid Reza Namvar, Amir Mohammad Shabani, Ebrahim Salehifar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-01-01
Series:Journal of Research in Pharmacy Practice
Subjects:
n-acetylcysteine
peripheral neuropathy
paclitaxel
Online Access:https://journals.lww.com/10.4103/jrpp.jrpp_18_25
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