PPARs in Irradiation-Induced Gastrointestinal Toxicity
The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/528327 |
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| _version_ | 1832565608061861888 |
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| author | Christine Linard Maâmar Souidi |
| author_facet | Christine Linard Maâmar Souidi |
| author_sort | Christine Linard |
| collection | DOAJ |
| description | The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and they decrease therapeutic benefit by increasing the overall treatment time. Emerging evidence indicates that PPARs and their ligands are important in the modulation of immune and inflammatory reactions. This paper discusses the effects of abdominal irradiation on PPARs, their role and functions in irradiation toxicity, and the possibility of using their ligands for radioprotection. |
| format | Article |
| id | doaj-art-cb92a8ed16d4429a932abcfdbcd5ba6f |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-cb92a8ed16d4429a932abcfdbcd5ba6f2025-02-03T01:07:19ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/528327528327PPARs in Irradiation-Induced Gastrointestinal ToxicityChristine Linard0Maâmar Souidi1Institute for Radioprotection and Nuclear Safety, B.P. no.17, 92262 Fontenay aux Roses Cedex, FranceInstitute for Radioprotection and Nuclear Safety, B.P. no.17, 92262 Fontenay aux Roses Cedex, FranceThe use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and they decrease therapeutic benefit by increasing the overall treatment time. Emerging evidence indicates that PPARs and their ligands are important in the modulation of immune and inflammatory reactions. This paper discusses the effects of abdominal irradiation on PPARs, their role and functions in irradiation toxicity, and the possibility of using their ligands for radioprotection.http://dx.doi.org/10.1155/2010/528327 |
| spellingShingle | Christine Linard Maâmar Souidi PPARs in Irradiation-Induced Gastrointestinal Toxicity PPAR Research |
| title | PPARs in Irradiation-Induced Gastrointestinal Toxicity |
| title_full | PPARs in Irradiation-Induced Gastrointestinal Toxicity |
| title_fullStr | PPARs in Irradiation-Induced Gastrointestinal Toxicity |
| title_full_unstemmed | PPARs in Irradiation-Induced Gastrointestinal Toxicity |
| title_short | PPARs in Irradiation-Induced Gastrointestinal Toxicity |
| title_sort | ppars in irradiation induced gastrointestinal toxicity |
| url | http://dx.doi.org/10.1155/2010/528327 |
| work_keys_str_mv | AT christinelinard pparsinirradiationinducedgastrointestinaltoxicity AT maamarsouidi pparsinirradiationinducedgastrointestinaltoxicity |