Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator supp...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/560194 |
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| _version_ | 1832562699248074752 |
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| author | Ying-Gang Zhu Jie-Ming Qu Jing Zhang Hong-Ni Jiang Jin-Fu Xu |
| author_facet | Ying-Gang Zhu Jie-Ming Qu Jing Zhang Hong-Ni Jiang Jin-Fu Xu |
| author_sort | Ying-Gang Zhu |
| collection | DOAJ |
| description | Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator support are still controversial. More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. Recently, the combination of cell and gene therapy which has been demonstrated to provide additive benefit has opened up a new chapter in therapeutic strategy and provides a basis for the development of an innovative approach for the prevention and treatment of ALI/ARDS. |
| format | Article |
| id | doaj-art-cb8a58b63ff64687a001ea6dd49b3526 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cb8a58b63ff64687a001ea6dd49b35262025-02-03T01:22:08ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/560194560194Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene TherapyYing-Gang Zhu0Jie-Ming Qu1Jing Zhang2Hong-Ni Jiang3Jin-Fu Xu4Department of Pulmonary Medicine, Huadong Hospital, Shanghai 200040, ChinaDepartment of Pulmonary Medicine, Huadong Hospital, Shanghai 200040, ChinaShanghai Medical School of Fudan University, Shanghai 200032, ChinaShanghai Medical School of Fudan University, Shanghai 200032, ChinaDepartment of Pulmonary Medicine, Shanghai Pulmonology Hospital, Tongji University, Shanghai 200043, ChinaAcute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator support are still controversial. More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. Recently, the combination of cell and gene therapy which has been demonstrated to provide additive benefit has opened up a new chapter in therapeutic strategy and provides a basis for the development of an innovative approach for the prevention and treatment of ALI/ARDS.http://dx.doi.org/10.1155/2011/560194 |
| spellingShingle | Ying-Gang Zhu Jie-Ming Qu Jing Zhang Hong-Ni Jiang Jin-Fu Xu Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy Mediators of Inflammation |
| title | Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy |
| title_full | Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy |
| title_fullStr | Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy |
| title_full_unstemmed | Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy |
| title_short | Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy |
| title_sort | novel interventional approaches for ali ards cell based gene therapy |
| url | http://dx.doi.org/10.1155/2011/560194 |
| work_keys_str_mv | AT yinggangzhu novelinterventionalapproachesforaliardscellbasedgenetherapy AT jiemingqu novelinterventionalapproachesforaliardscellbasedgenetherapy AT jingzhang novelinterventionalapproachesforaliardscellbasedgenetherapy AT hongnijiang novelinterventionalapproachesforaliardscellbasedgenetherapy AT jinfuxu novelinterventionalapproachesforaliardscellbasedgenetherapy |