How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases
Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease will contribute to finding novel and preventive...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/3696914 |
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| _version_ | 1832549887793692672 |
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| author | Wenyi Zhou Mingyi Zhao |
| author_facet | Wenyi Zhou Mingyi Zhao |
| author_sort | Wenyi Zhou |
| collection | DOAJ |
| description | Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease will contribute to finding novel and preventive therapeutic methods. The canonical Hippo tumor suppressor pathway in mammalian cells is primarily composed of the MST1/2-SAV1-LATS1/2-MOB1-YAP/TAZ cascade. Continuing research on this pathway has identified other factors like RASSF1A, Nf2, MAP4Ks, and NDR1/2, further enriching our knowledge of the Hippo-YAP pathway. YAP, the core effecter of the Hippo pathway, may accumulate in the nucleus and initiate transcriptional activity if the pathway is inhibited. The role of Hippo signaling has been widely investigated in organ development and cancers. A heart of normal size and function which is critical for survival could not be generated without the proper regulation of the Hippo tumor suppressor pathway. Recent research has demonstrated a novel role of Hippo signaling in cardiovascular disease in the context of development, hypertrophy, angiogenesis, regeneration, apoptosis, and autophagy. In this review, we summarize the current knowledge of how Hippo signaling modulates pathological processes in cardiovascular disease and discuss potential molecular therapeutic targets. |
| format | Article |
| id | doaj-art-cb7db269f3fd486c93ff8841a807c531 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cb7db269f3fd486c93ff8841a807c5312025-02-03T06:08:19ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/36969143696914How Hippo Signaling Pathway Modulates Cardiovascular Development and DiseasesWenyi Zhou0Mingyi Zhao1Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaCardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease will contribute to finding novel and preventive therapeutic methods. The canonical Hippo tumor suppressor pathway in mammalian cells is primarily composed of the MST1/2-SAV1-LATS1/2-MOB1-YAP/TAZ cascade. Continuing research on this pathway has identified other factors like RASSF1A, Nf2, MAP4Ks, and NDR1/2, further enriching our knowledge of the Hippo-YAP pathway. YAP, the core effecter of the Hippo pathway, may accumulate in the nucleus and initiate transcriptional activity if the pathway is inhibited. The role of Hippo signaling has been widely investigated in organ development and cancers. A heart of normal size and function which is critical for survival could not be generated without the proper regulation of the Hippo tumor suppressor pathway. Recent research has demonstrated a novel role of Hippo signaling in cardiovascular disease in the context of development, hypertrophy, angiogenesis, regeneration, apoptosis, and autophagy. In this review, we summarize the current knowledge of how Hippo signaling modulates pathological processes in cardiovascular disease and discuss potential molecular therapeutic targets.http://dx.doi.org/10.1155/2018/3696914 |
| spellingShingle | Wenyi Zhou Mingyi Zhao How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases Journal of Immunology Research |
| title | How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases |
| title_full | How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases |
| title_fullStr | How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases |
| title_full_unstemmed | How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases |
| title_short | How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases |
| title_sort | how hippo signaling pathway modulates cardiovascular development and diseases |
| url | http://dx.doi.org/10.1155/2018/3696914 |
| work_keys_str_mv | AT wenyizhou howhipposignalingpathwaymodulatescardiovasculardevelopmentanddiseases AT mingyizhao howhipposignalingpathwaymodulatescardiovasculardevelopmentanddiseases |