Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis
We present the case of a 46-year old patient with Child-Pugh class C cirrhosis with MEDL-Score 16, and hepatocellular carcinoma invading the inferior vena cava and the right atrium. The etiology of cirrhosis is type 1 hereditary hemochromatosis with positive HFE C282Y/C282Y and H63D/H63D mutations....
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Journal of Mind and Medical Sciences |
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| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1117&context=jmms |
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| author | Olga Hilda Orasan Andreea Maria Stefan Laura Urian Anca Mihailov Ovidiu Fabian Flaviu Muresan Iulia Breaban Sorina Cezara Secara Simina Tarmure Sarlea Vasile Negrean Dorel Sampelean Angela Cozma |
| author_facet | Olga Hilda Orasan Andreea Maria Stefan Laura Urian Anca Mihailov Ovidiu Fabian Flaviu Muresan Iulia Breaban Sorina Cezara Secara Simina Tarmure Sarlea Vasile Negrean Dorel Sampelean Angela Cozma |
| author_sort | Olga Hilda Orasan |
| collection | DOAJ |
| description | We present the case of a 46-year old patient with Child-Pugh class C cirrhosis with MEDL-Score 16, and hepatocellular carcinoma invading the inferior vena cava and the right atrium. The etiology of cirrhosis is type 1 hereditary hemochromatosis with positive HFE C282Y/C282Y and H63D/H63D mutations. A systematic review of the literature was performed and only 30 cases of hepatocellular carcinoma with tumor thrombosis extending into the right atrium have been described. To our knowledge, this is the first case that evidences the presence in hereditary hemochromatosis of hepatocellular carcinoma with atypical invasion into the right atrium. Screening of patients with a family history of hereditary hemochromatosis allows detection of the disease in the asymptomatic phase, allowing initiation of early therapy and improved prognosis. |
| format | Article |
| id | doaj-art-cb5d36c8e8bd45f9b9d8a0ae202ec91e |
| institution | DOAJ |
| issn | 2392-7674 2392-7674 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-cb5d36c8e8bd45f9b9d8a0ae202ec91e2025-08-20T02:54:36ZengMDPI AGJournal of Mind and Medical Sciences2392-76742392-76742018-10-015230030410.22543/7674.52.P300304Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosisOlga Hilda Orasan0Andreea Maria Stefan1Laura Urian2Anca Mihailov3Ovidiu Fabian4Flaviu Muresan5Iulia Breaban6Sorina Cezara Secara7Simina Tarmure Sarlea8Vasile Negrean9Dorel Sampelean10Angela Cozma11Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania Prof. Dr. Octavian Fodor, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Department of Hematology, Cluj-Napoca, Romania Railway Hospital, 4th Surgical Department, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Surgery, ClujNapoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Surgery, ClujNapoca, RomaniaProf. Dr. Octavian Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, RomaniaProf. Dr. Octavian Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania We present the case of a 46-year old patient with Child-Pugh class C cirrhosis with MEDL-Score 16, and hepatocellular carcinoma invading the inferior vena cava and the right atrium. The etiology of cirrhosis is type 1 hereditary hemochromatosis with positive HFE C282Y/C282Y and H63D/H63D mutations. A systematic review of the literature was performed and only 30 cases of hepatocellular carcinoma with tumor thrombosis extending into the right atrium have been described. To our knowledge, this is the first case that evidences the presence in hereditary hemochromatosis of hepatocellular carcinoma with atypical invasion into the right atrium. Screening of patients with a family history of hereditary hemochromatosis allows detection of the disease in the asymptomatic phase, allowing initiation of early therapy and improved prognosis.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1117&context=jmmsright atrial tumor thrombushepatocellular carcinomahereditary hemochromatosis |
| spellingShingle | Olga Hilda Orasan Andreea Maria Stefan Laura Urian Anca Mihailov Ovidiu Fabian Flaviu Muresan Iulia Breaban Sorina Cezara Secara Simina Tarmure Sarlea Vasile Negrean Dorel Sampelean Angela Cozma Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis Journal of Mind and Medical Sciences right atrial tumor thrombus hepatocellular carcinoma hereditary hemochromatosis |
| title | Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis |
| title_full | Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis |
| title_fullStr | Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis |
| title_full_unstemmed | Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis |
| title_short | Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis |
| title_sort | hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis |
| topic | right atrial tumor thrombus hepatocellular carcinoma hereditary hemochromatosis |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1117&context=jmms |
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