Amiloride-Sensitive Sodium Channels and Pulmonary Edema
The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance. An important mechanism regulating alveolar fluid clearance is...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/830320 |
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| _version_ | 1832556219749892096 |
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| author | Mike Althaus Wolfgang G. Clauss Martin Fronius |
| author_facet | Mike Althaus Wolfgang G. Clauss Martin Fronius |
| author_sort | Mike Althaus |
| collection | DOAJ |
| description | The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance. An important mechanism regulating alveolar fluid clearance is sodium transport across the alveolar epithelium. Transepithelial sodium transport is largely dependent on the activity of sodium channels in alveolar epithelial cells. This paper describes how sodium channels contribute to alveolar fluid clearance under physiological conditions and how deregulation of sodium channel activity might contribute to the pathogenesis of lung diseases associated with pulmonary edema. Furthermore, sodium channels as putative molecular targets for the treatment of pulmonary edema are discussed. |
| format | Article |
| id | doaj-art-cb5caf18679b449fa4ec58a15520d15e |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-cb5caf18679b449fa4ec58a15520d15e2025-02-03T05:46:06ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/830320830320Amiloride-Sensitive Sodium Channels and Pulmonary EdemaMike Althaus0Wolfgang G. Clauss1Martin Fronius2Institute of Animal Physiology, Justus-Liebig University of Giessen, Wartweg 95, 35392 Giessen, GermanyInstitute of Animal Physiology, Justus-Liebig University of Giessen, Wartweg 95, 35392 Giessen, GermanyInstitute of Animal Physiology, Justus-Liebig University of Giessen, Wartweg 95, 35392 Giessen, GermanyThe development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance. An important mechanism regulating alveolar fluid clearance is sodium transport across the alveolar epithelium. Transepithelial sodium transport is largely dependent on the activity of sodium channels in alveolar epithelial cells. This paper describes how sodium channels contribute to alveolar fluid clearance under physiological conditions and how deregulation of sodium channel activity might contribute to the pathogenesis of lung diseases associated with pulmonary edema. Furthermore, sodium channels as putative molecular targets for the treatment of pulmonary edema are discussed.http://dx.doi.org/10.1155/2011/830320 |
| spellingShingle | Mike Althaus Wolfgang G. Clauss Martin Fronius Amiloride-Sensitive Sodium Channels and Pulmonary Edema Pulmonary Medicine |
| title | Amiloride-Sensitive Sodium Channels and Pulmonary Edema |
| title_full | Amiloride-Sensitive Sodium Channels and Pulmonary Edema |
| title_fullStr | Amiloride-Sensitive Sodium Channels and Pulmonary Edema |
| title_full_unstemmed | Amiloride-Sensitive Sodium Channels and Pulmonary Edema |
| title_short | Amiloride-Sensitive Sodium Channels and Pulmonary Edema |
| title_sort | amiloride sensitive sodium channels and pulmonary edema |
| url | http://dx.doi.org/10.1155/2011/830320 |
| work_keys_str_mv | AT mikealthaus amiloridesensitivesodiumchannelsandpulmonaryedema AT wolfganggclauss amiloridesensitivesodiumchannelsandpulmonaryedema AT martinfronius amiloridesensitivesodiumchannelsandpulmonaryedema |