Lifelong cardiovascular care in Turner syndrome: two cases with review of literature
Cardiovascular disease is one of the most important complications in girls and women with Turner syndrome (TS). Although the latest international guideline provides useful suggestions for the management of cardiovascular diseases in TS, some unknown cardiac conditions warrant physicians’ attention a...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-07-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0038/_html/-char/en |
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| author | Shun Moriguchi Yuri Mukoyama Fumihiko Takizawa Atsushi Ogawa Tetsushi Ogawa Junko Ito Yukishige Yanagawa Chinatsu Komiyama Rieko Niitsu Tsuyoshi Isojima |
| author_facet | Shun Moriguchi Yuri Mukoyama Fumihiko Takizawa Atsushi Ogawa Tetsushi Ogawa Junko Ito Yukishige Yanagawa Chinatsu Komiyama Rieko Niitsu Tsuyoshi Isojima |
| author_sort | Shun Moriguchi |
| collection | DOAJ |
| description | Cardiovascular disease is one of the most important complications in girls and women with Turner syndrome (TS). Although the latest international guideline provides useful suggestions for the management of cardiovascular diseases in TS, some unknown cardiac conditions warrant physicians’ attention and awareness. Here, we have reported two adult cases wherein significant cardiovascular diseases were detected during the transition period. The first case patient was diagnosed with aortic crank deformity and left subclavian artery aneurysm at 14 years based on the report of cardiac catheterization, computed tomography angiography, and cardiac magnetic resonance imaging, which had remained undetected by annual evaluations using transthoracic echocardiography (TTE). This case emphasizes the importance of cardiac reevaluation during the transition period. The second case patient was diagnosed with moderate mitral valve regurgitation (MR) due to mitral valve prolapse at 18 years through TTE, although the first evaluation at 7 years by TTE detected slight MR without any clinical concerns. The condition however progressed to severe MR at 28 years, requiring mitral valvuloplasty. MR is the most common valve disease worldwide, which makes it challenging to comprehend whether the condition is a complication. However, the condition requiring surgery at this age is extremely rare, which implies the possibility of early progression. Because almost all literature on cardiovascular complications in TS is cross-sectional, further information about longitudinal cardiovascular conditions is vital for optimal care for girls and women with TS. The two cases reported in this article provide significant information for improving lifelong cardiovascular health issues in TS. |
| format | Article |
| id | doaj-art-cb58e2361d014ca788231b1d2cc76869 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-cb58e2361d014ca788231b1d2cc768692025-01-22T05:12:18ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-07-0171771371910.1507/endocrj.EJ24-0038endocrjLifelong cardiovascular care in Turner syndrome: two cases with review of literatureShun Moriguchi0Yuri Mukoyama1Fumihiko Takizawa2Atsushi Ogawa3Tetsushi Ogawa4Junko Ito5Yukishige Yanagawa6Chinatsu Komiyama7Rieko Niitsu8Tsuyoshi Isojima9Department of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Cardiology, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Cardiology, Toranomon Hospital, Tokyo 105-8470, JapanDepartment of Pediatrics, Toranomon Hospital, Tokyo 105-8470, JapanCardiovascular disease is one of the most important complications in girls and women with Turner syndrome (TS). Although the latest international guideline provides useful suggestions for the management of cardiovascular diseases in TS, some unknown cardiac conditions warrant physicians’ attention and awareness. Here, we have reported two adult cases wherein significant cardiovascular diseases were detected during the transition period. The first case patient was diagnosed with aortic crank deformity and left subclavian artery aneurysm at 14 years based on the report of cardiac catheterization, computed tomography angiography, and cardiac magnetic resonance imaging, which had remained undetected by annual evaluations using transthoracic echocardiography (TTE). This case emphasizes the importance of cardiac reevaluation during the transition period. The second case patient was diagnosed with moderate mitral valve regurgitation (MR) due to mitral valve prolapse at 18 years through TTE, although the first evaluation at 7 years by TTE detected slight MR without any clinical concerns. The condition however progressed to severe MR at 28 years, requiring mitral valvuloplasty. MR is the most common valve disease worldwide, which makes it challenging to comprehend whether the condition is a complication. However, the condition requiring surgery at this age is extremely rare, which implies the possibility of early progression. Because almost all literature on cardiovascular complications in TS is cross-sectional, further information about longitudinal cardiovascular conditions is vital for optimal care for girls and women with TS. The two cases reported in this article provide significant information for improving lifelong cardiovascular health issues in TS.https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0038/_html/-char/enturner syndromecardiovascular healthtransitioncomplication |
| spellingShingle | Shun Moriguchi Yuri Mukoyama Fumihiko Takizawa Atsushi Ogawa Tetsushi Ogawa Junko Ito Yukishige Yanagawa Chinatsu Komiyama Rieko Niitsu Tsuyoshi Isojima Lifelong cardiovascular care in Turner syndrome: two cases with review of literature Endocrine Journal turner syndrome cardiovascular health transition complication |
| title | Lifelong cardiovascular care in Turner syndrome: two cases with review of literature |
| title_full | Lifelong cardiovascular care in Turner syndrome: two cases with review of literature |
| title_fullStr | Lifelong cardiovascular care in Turner syndrome: two cases with review of literature |
| title_full_unstemmed | Lifelong cardiovascular care in Turner syndrome: two cases with review of literature |
| title_short | Lifelong cardiovascular care in Turner syndrome: two cases with review of literature |
| title_sort | lifelong cardiovascular care in turner syndrome two cases with review of literature |
| topic | turner syndrome cardiovascular health transition complication |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0038/_html/-char/en |
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