Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity

Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity

IntroductionTesticular Leydig cells are responsible for producing almost all the testosterone required by men throughout the lifespan, with reduced testosterone (hypogonadism) correlating with age-linked morbidity and mortality. Leydig cells derive from stem cells within the testes after birth. Thes...

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Bibliographic Details
Main Authors: Bilal Tulumcu, Richard Ivell, Waleed Alhujaili, Ravinder Anand-Ivell
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Endocrinology
Subjects:
ALSPAC
INSL3
Leydig cell
hypogonadism
puberty
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1574760/full
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