Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway
Background and Purpose. Metformin, a widely used antidiabetic drug, has been shown to have anti-inflammatory properties; nevertheless, its influence on β-cell meta-inflammation remains unclear. The following study investigated the effects of metformin on meta-inflammatory in β-cells and whether the...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/7602427 |
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| _version_ | 1832566640359768064 |
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| author | Ximei Shen Beibei Fan Xin Hu Liufen Luo Yuanli Yan Liyong Yang |
| author_facet | Ximei Shen Beibei Fan Xin Hu Liufen Luo Yuanli Yan Liyong Yang |
| author_sort | Ximei Shen |
| collection | DOAJ |
| description | Background and Purpose. Metformin, a widely used antidiabetic drug, has been shown to have anti-inflammatory properties; nevertheless, its influence on β-cell meta-inflammation remains unclear. The following study investigated the effects of metformin on meta-inflammatory in β-cells and whether the underlying mechanisms were associated with the G protein-coupled receptor 40-phospholipase C-inositol 1, 4, 5-trisphosphate (GPR40-PLC-IP3) pathway. Materials and Methods. Lipotoxicity-induced β-cells and the high-fat diet-induced obese rat model were used in the study. Results. Metformin-reduced lipotoxicity-induced β-cell meta-inflammatory injury was associated with the expression of GPR40. GPR40 was involved in metformin reversing metabolic inflammation key marker TLR4 activation-mediated β-cell injury. Furthermore, downstream signaling protein PLC-IP3 of GPR40 was involved in the protective effect of metformin on meta-inflammation, and the above process of metformin was partially regulated by AMPK activity. In addition, the anti-inflammatory effects of metformin were observed in obese rats. Conclusion. Metformin can reduce lipotoxicity-induced meta-inflammation in β-cells through the regulation of the GPR40-PLC-IP3 pathway and partially via the regulation of AMPK activity. |
| format | Article |
| id | doaj-art-cb471f959d4f45da8832e1fdc517826b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-cb471f959d4f45da8832e1fdc517826b2025-02-03T01:03:38ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/76024277602427Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 PathwayXimei Shen0Beibei Fan1Xin Hu2Liufen Luo3Yuanli Yan4Liyong Yang5Endocrinology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 Fujian, ChinaEndocrinology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 Fujian, ChinaEndocrinology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 Fujian, ChinaEndocrinology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 Fujian, ChinaEndocrinology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 Fujian, ChinaEndocrinology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 Fujian, ChinaBackground and Purpose. Metformin, a widely used antidiabetic drug, has been shown to have anti-inflammatory properties; nevertheless, its influence on β-cell meta-inflammation remains unclear. The following study investigated the effects of metformin on meta-inflammatory in β-cells and whether the underlying mechanisms were associated with the G protein-coupled receptor 40-phospholipase C-inositol 1, 4, 5-trisphosphate (GPR40-PLC-IP3) pathway. Materials and Methods. Lipotoxicity-induced β-cells and the high-fat diet-induced obese rat model were used in the study. Results. Metformin-reduced lipotoxicity-induced β-cell meta-inflammatory injury was associated with the expression of GPR40. GPR40 was involved in metformin reversing metabolic inflammation key marker TLR4 activation-mediated β-cell injury. Furthermore, downstream signaling protein PLC-IP3 of GPR40 was involved in the protective effect of metformin on meta-inflammation, and the above process of metformin was partially regulated by AMPK activity. In addition, the anti-inflammatory effects of metformin were observed in obese rats. Conclusion. Metformin can reduce lipotoxicity-induced meta-inflammation in β-cells through the regulation of the GPR40-PLC-IP3 pathway and partially via the regulation of AMPK activity.http://dx.doi.org/10.1155/2019/7602427 |
| spellingShingle | Ximei Shen Beibei Fan Xin Hu Liufen Luo Yuanli Yan Liyong Yang Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway Journal of Diabetes Research |
| title | Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway |
| title_full | Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway |
| title_fullStr | Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway |
| title_full_unstemmed | Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway |
| title_short | Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway |
| title_sort | metformin reduces lipotoxicity induced meta inflammation in β cells through the activation of gpr40 plc ip3 pathway |
| url | http://dx.doi.org/10.1155/2019/7602427 |
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