Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study
BackgroundSepsis is defined as a dysregulated host response to infection that results in life-threatening organ dysfunction. The 24-hour urine volume plays a crucial role in assessing the prognosis of septic patients. This study aims to investigate the relationship between 24-hour urine volume and 2...
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Frontiers Media S.A.
2024-11-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1486232/full |
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| author | Yuzhan Lin Weiguo Lin Cheng Fu Ruixue Sun WeiLi Hong Xinglin Chen Shaorong Yan |
| author_facet | Yuzhan Lin Weiguo Lin Cheng Fu Ruixue Sun WeiLi Hong Xinglin Chen Shaorong Yan |
| author_sort | Yuzhan Lin |
| collection | DOAJ |
| description | BackgroundSepsis is defined as a dysregulated host response to infection that results in life-threatening organ dysfunction. The 24-hour urine volume plays a crucial role in assessing the prognosis of septic patients. This study aims to investigate the relationship between 24-hour urine volume and 28-day intensive care unit (ICU) mortality in septic patients and exploring the dose-response relationship between these variables.MethodsThis retrospective cohort study analyzed data from 7,218 sepsis patients in the eICU Collaborative Research Database. Logistic regression models and generalized additive models were used to examine the relationship between 24-hour urine volume and 28-day ICU mortality.ResultsA negative correlation was found between 24-hour urine volume and ICU 28-day mortality. In the fully adjusted model, each 50 mL increase in 24-hour urine volume significantly reduced mortality risk by 1% (OR = 0.99, 95% CI = 0.98–0.99, P < 0.001). A nonlinear dose-response relationship was observed, with an inflection point at ~1,663.5 ml. Below this threshold, increased urine volume was significantly associated with reduced mortality risk (OR = 0.97, 95% CI: 0.96–0.98, P < 0.001), while above this point, the relationship was not statistically significant.ConclusionThis study demonstrates a non-linear negative correlation between 24-hour urine volume and 28-day ICU mortality in sepsis patients. |
| format | Article |
| id | doaj-art-cb3e7fcd74e64c5a89436c3ea6f1ac96 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-cb3e7fcd74e64c5a89436c3ea6f1ac962025-01-31T10:59:26ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-11-011110.3389/fmed.2024.14862321486232Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort studyYuzhan Lin0Weiguo Lin1Cheng Fu2Ruixue Sun3WeiLi Hong4Xinglin Chen5Shaorong Yan6Department of Clinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, ChinaDepartment of Urology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, ChinaDepartment of Clinical Laboratory, Ruian Traditional Chinese Medicine Hospital, Ruian, Zhejiang, ChinaDepartment of Clinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, ChinaDepartment of Emergency Intensive Care Unit, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, ChinaDepartment of Epidemiology and Biostatistics, Empower U, X&Y Solutions Inc., Boston, MA, United StatesDepartment of Clinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, ChinaBackgroundSepsis is defined as a dysregulated host response to infection that results in life-threatening organ dysfunction. The 24-hour urine volume plays a crucial role in assessing the prognosis of septic patients. This study aims to investigate the relationship between 24-hour urine volume and 28-day intensive care unit (ICU) mortality in septic patients and exploring the dose-response relationship between these variables.MethodsThis retrospective cohort study analyzed data from 7,218 sepsis patients in the eICU Collaborative Research Database. Logistic regression models and generalized additive models were used to examine the relationship between 24-hour urine volume and 28-day ICU mortality.ResultsA negative correlation was found between 24-hour urine volume and ICU 28-day mortality. In the fully adjusted model, each 50 mL increase in 24-hour urine volume significantly reduced mortality risk by 1% (OR = 0.99, 95% CI = 0.98–0.99, P < 0.001). A nonlinear dose-response relationship was observed, with an inflection point at ~1,663.5 ml. Below this threshold, increased urine volume was significantly associated with reduced mortality risk (OR = 0.97, 95% CI: 0.96–0.98, P < 0.001), while above this point, the relationship was not statistically significant.ConclusionThis study demonstrates a non-linear negative correlation between 24-hour urine volume and 28-day ICU mortality in sepsis patients.https://www.frontiersin.org/articles/10.3389/fmed.2024.1486232/fulldose-response relationshipintensive care unitmortalitysepsisurine volume |
| spellingShingle | Yuzhan Lin Weiguo Lin Cheng Fu Ruixue Sun WeiLi Hong Xinglin Chen Shaorong Yan Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study Frontiers in Medicine dose-response relationship intensive care unit mortality sepsis urine volume |
| title | Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study |
| title_full | Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study |
| title_fullStr | Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study |
| title_full_unstemmed | Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study |
| title_short | Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study |
| title_sort | association between 24 hour urine volume and 28 day intensive care unit mortality in sepsis patients a multi center retrospective cohort study |
| topic | dose-response relationship intensive care unit mortality sepsis urine volume |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1486232/full |
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