Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury
Background. Despite a lack of clear evidence, multiple neurostimulants are commonly provided after severe brain injury (BI). The purpose of this study is to determine if the number of neurostimulants received during rehabilitation was associated with recovery of full consciousness or improved neurob...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/964578 |
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| author | Amy A. Herrold Theresa Louise-Bender Pape Ann Guernon Trudy Mallinson Eileen Collins Neil Jordan |
| author_facet | Amy A. Herrold Theresa Louise-Bender Pape Ann Guernon Trudy Mallinson Eileen Collins Neil Jordan |
| author_sort | Amy A. Herrold |
| collection | DOAJ |
| description | Background. Despite a lack of clear evidence, multiple neurostimulants are commonly provided after severe brain injury (BI). The purpose of this study is to determine if the number of neurostimulants received during rehabilitation was associated with recovery of full consciousness or improved neurobehavioral function after severe BI. Method. Data from 115 participants were extracted from a neurobehavioral observational study database for this exploratory, retrospective analysis. Univariate optimal data analysis was conducted to determine if the number of neurostimulants influenced classification of four outcomes: recovery of full consciousness during rehabilitation, recovery of full consciousness within one year of injury, and meaningful neurobehavioral improvement during rehabilitation defined as either at least a 4.7 unit (minimal detectable change) or 2.58 unit (minimal clinically important difference) gain on the Disorders of Consciousness Scale-25 (DOCS-25). Results. Number of neurostimulants was not significantly (P>0.05) associated with recovery of full consciousness during rehabilitation, within one year of injury, or meaningful neurobehavioral improvement using the DOCS-25. Conclusions. Receiving multiple neurostimulants during rehabilitation may not influence recovery of full consciousness or meaningful neurobehavioral improvement. Given costs associated with additional medication, future research is needed to guide physicians about the merits of prescribing multiple neurostimulants during rehabilitation after severe BI. |
| format | Article |
| id | doaj-art-cb3254fbc61e495daceeebacd0ef047b |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cb3254fbc61e495daceeebacd0ef047b2025-02-03T01:31:27ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/964578964578Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain InjuryAmy A. Herrold0Theresa Louise-Bender Pape1Ann Guernon2Trudy Mallinson3Eileen Collins4Neil Jordan5Edward Hines Jr. VA Hospital Research Service, P.O. Box 5000, S. Fifth Avenue (M/C 151H), Hines, IL 60141, USAEdward Hines Jr. VA Hospital Research Service, P.O. Box 5000, S. Fifth Avenue (M/C 151H), Hines, IL 60141, USAEdward Hines Jr. VA Hospital Research Service, P.O. Box 5000, S. Fifth Avenue (M/C 151H), Hines, IL 60141, USADepartment of Clinical Research and Leadership, The George Washington University, 2100 Pennsylvania Avenue, Washington, DC 20037, USAEdward Hines Jr. VA Hospital Research Service, P.O. Box 5000, S. Fifth Avenue (M/C 151H), Hines, IL 60141, USAEdward Hines Jr. VA Hospital Research Service, P.O. Box 5000, S. Fifth Avenue (M/C 151H), Hines, IL 60141, USABackground. Despite a lack of clear evidence, multiple neurostimulants are commonly provided after severe brain injury (BI). The purpose of this study is to determine if the number of neurostimulants received during rehabilitation was associated with recovery of full consciousness or improved neurobehavioral function after severe BI. Method. Data from 115 participants were extracted from a neurobehavioral observational study database for this exploratory, retrospective analysis. Univariate optimal data analysis was conducted to determine if the number of neurostimulants influenced classification of four outcomes: recovery of full consciousness during rehabilitation, recovery of full consciousness within one year of injury, and meaningful neurobehavioral improvement during rehabilitation defined as either at least a 4.7 unit (minimal detectable change) or 2.58 unit (minimal clinically important difference) gain on the Disorders of Consciousness Scale-25 (DOCS-25). Results. Number of neurostimulants was not significantly (P>0.05) associated with recovery of full consciousness during rehabilitation, within one year of injury, or meaningful neurobehavioral improvement using the DOCS-25. Conclusions. Receiving multiple neurostimulants during rehabilitation may not influence recovery of full consciousness or meaningful neurobehavioral improvement. Given costs associated with additional medication, future research is needed to guide physicians about the merits of prescribing multiple neurostimulants during rehabilitation after severe BI.http://dx.doi.org/10.1155/2014/964578 |
| spellingShingle | Amy A. Herrold Theresa Louise-Bender Pape Ann Guernon Trudy Mallinson Eileen Collins Neil Jordan Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury The Scientific World Journal |
| title | Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury |
| title_full | Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury |
| title_fullStr | Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury |
| title_full_unstemmed | Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury |
| title_short | Prescribing Multiple Neurostimulants during Rehabilitation for Severe Brain Injury |
| title_sort | prescribing multiple neurostimulants during rehabilitation for severe brain injury |
| url | http://dx.doi.org/10.1155/2014/964578 |
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