Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus
Background/Objectives. Endothelial dysfunction due to hyperglycemia-induced oxidative damage is an important predictor of future cardiovascular risk in patients with type 1 diabetes mellitus (T1DM) and is present in adolescent T1DM. We hypothesized that combined treatment with the antioxidant vitam...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/3271293 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548085846245376 |
|---|---|
| author | Rachel-Marie Cazeau Hong Huang John A. Bauer Robert P. Hoffman |
| author_facet | Rachel-Marie Cazeau Hong Huang John A. Bauer Robert P. Hoffman |
| author_sort | Rachel-Marie Cazeau |
| collection | DOAJ |
| description | Background/Objectives. Endothelial dysfunction due to hyperglycemia-induced oxidative damage is an important predictor of future cardiovascular risk in patients with type 1 diabetes mellitus (T1DM) and is present in adolescent T1DM. We hypothesized that combined treatment with the antioxidant vitamins C and E might improve endothelial function (EF) and other biochemical risk factors in adolescents with T1DM. Subjects/Methods. Open-label antioxidant supplementation was given for six weeks with endpoint measurements collected at baseline and study completion. Endpoints measured included EF and plasma measurements of biochemical endothelial risk. Results. Two males and 7 females were studied. Mean age was 12.9 ± 0.9 yrs; mean T1DM duration was 5.5 ± 2.5 yrs; mean BMI was 22.1 ± 3.8 kg/m2; and mean hemoglobin A1c was 9.3 ± 1.1%. No differences were found for EF, high sensitivity CRP, total antioxidant capacity, adiponectin, or endothelial progenitor cells (EPCs) between before and after combined vitamin C and E therapy. Conclusions. Our negative study results do not support previous findings of decreased oxidative damage, improved endothelial function, and increased vascular repair capacity with antioxidant therapy. Longer term studies may be needed to determine the effects, if any, of combined antioxidant therapy on EPCs, EF, and markers of micro- and macrovascular complications in T1DM. |
| format | Article |
| id | doaj-art-cb2f1796708548d4924b4b36a962daf4 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-cb2f1796708548d4924b4b36a962daf42025-02-03T06:42:21ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/32712933271293Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes MellitusRachel-Marie Cazeau0Hong Huang1John A. Bauer2Robert P. Hoffman3Section of Endocrinology, Metabolism and Diabetes, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USADepartment of Pediatrics, University of Kentucky, Lexington, KY 40506, USADepartment of Pediatrics, University of Kentucky, Lexington, KY 40506, USASection of Endocrinology, Metabolism and Diabetes, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USABackground/Objectives. Endothelial dysfunction due to hyperglycemia-induced oxidative damage is an important predictor of future cardiovascular risk in patients with type 1 diabetes mellitus (T1DM) and is present in adolescent T1DM. We hypothesized that combined treatment with the antioxidant vitamins C and E might improve endothelial function (EF) and other biochemical risk factors in adolescents with T1DM. Subjects/Methods. Open-label antioxidant supplementation was given for six weeks with endpoint measurements collected at baseline and study completion. Endpoints measured included EF and plasma measurements of biochemical endothelial risk. Results. Two males and 7 females were studied. Mean age was 12.9 ± 0.9 yrs; mean T1DM duration was 5.5 ± 2.5 yrs; mean BMI was 22.1 ± 3.8 kg/m2; and mean hemoglobin A1c was 9.3 ± 1.1%. No differences were found for EF, high sensitivity CRP, total antioxidant capacity, adiponectin, or endothelial progenitor cells (EPCs) between before and after combined vitamin C and E therapy. Conclusions. Our negative study results do not support previous findings of decreased oxidative damage, improved endothelial function, and increased vascular repair capacity with antioxidant therapy. Longer term studies may be needed to determine the effects, if any, of combined antioxidant therapy on EPCs, EF, and markers of micro- and macrovascular complications in T1DM.http://dx.doi.org/10.1155/2016/3271293 |
| spellingShingle | Rachel-Marie Cazeau Hong Huang John A. Bauer Robert P. Hoffman Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus Journal of Diabetes Research |
| title | Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus |
| title_full | Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus |
| title_fullStr | Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus |
| title_full_unstemmed | Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus |
| title_short | Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus |
| title_sort | effect of vitamins c and e on endothelial function in type 1 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2016/3271293 |
| work_keys_str_mv | AT rachelmariecazeau effectofvitaminscandeonendothelialfunctionintype1diabetesmellitus AT honghuang effectofvitaminscandeonendothelialfunctionintype1diabetesmellitus AT johnabauer effectofvitaminscandeonendothelialfunctionintype1diabetesmellitus AT robertphoffman effectofvitaminscandeonendothelialfunctionintype1diabetesmellitus |