Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRI
Lesion-symptom mapping studies are based upon the assumption that behavioral impairments are directly related to structural brain damage. Given what is known about the relationship between perfusion deficits and impairment in acute stroke, attributing specific behavioral impairments to localized bra...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-2011-0283 |
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| author | Jessica D. Richardson Julie M. Baker Paul S. Morgan Chris Rorden L. Bonilha Julius Fridriksson |
| author_facet | Jessica D. Richardson Julie M. Baker Paul S. Morgan Chris Rorden L. Bonilha Julius Fridriksson |
| author_sort | Jessica D. Richardson |
| collection | DOAJ |
| description | Lesion-symptom mapping studies are based upon the assumption that behavioral impairments are directly related to structural brain damage. Given what is known about the relationship between perfusion deficits and impairment in acute stroke, attributing specific behavioral impairments to localized brain damage leaves much room for speculation, as impairments could also reflect abnormal neurovascular function in brain regions that appear structurally intact on traditional CT and MRI scans. Compared to acute stroke, the understanding of cerebral perfusion in chronic stroke is far less clear. Utilizing arterial spin labeling (ASL) MRI, we examined perfusion in 17 patients with chronic left hemisphere stroke. The results revealed a decrease in left hemisphere perfusion, primarily in peri-infarct tissue. There was also a strong relationship between increased infarct size and decreased perfusion. These findings have implications for lesion-symptom mapping studies as well as research that relies on functional MRI to study chronic stroke. |
| format | Article |
| id | doaj-art-cb2c83b8453149688a1124da3eb1d37c |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-cb2c83b8453149688a1124da3eb1d37c2025-02-03T01:26:40ZengWileyBehavioural Neurology0953-41801875-85842011-01-0124211712210.3233/BEN-2011-0283Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRIJessica D. Richardson0Julie M. Baker1Paul S. Morgan2Chris Rorden3L. Bonilha4Julius Fridriksson5Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USADepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USADepartment of Radiology and Radiological Science, Medical University of South Carolina, Columbia, SC, USAGeorgia State/Georgia Tech Center for Advanced Brain Imaging, GA, USADepartment of Neurosciences, Medical University of South Carolina, Columbia, SC, USADepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USALesion-symptom mapping studies are based upon the assumption that behavioral impairments are directly related to structural brain damage. Given what is known about the relationship between perfusion deficits and impairment in acute stroke, attributing specific behavioral impairments to localized brain damage leaves much room for speculation, as impairments could also reflect abnormal neurovascular function in brain regions that appear structurally intact on traditional CT and MRI scans. Compared to acute stroke, the understanding of cerebral perfusion in chronic stroke is far less clear. Utilizing arterial spin labeling (ASL) MRI, we examined perfusion in 17 patients with chronic left hemisphere stroke. The results revealed a decrease in left hemisphere perfusion, primarily in peri-infarct tissue. There was also a strong relationship between increased infarct size and decreased perfusion. These findings have implications for lesion-symptom mapping studies as well as research that relies on functional MRI to study chronic stroke.http://dx.doi.org/10.3233/BEN-2011-0283 |
| spellingShingle | Jessica D. Richardson Julie M. Baker Paul S. Morgan Chris Rorden L. Bonilha Julius Fridriksson Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRI Behavioural Neurology |
| title | Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRI |
| title_full | Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRI |
| title_fullStr | Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRI |
| title_full_unstemmed | Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRI |
| title_short | Cerebral Perfusion in Chronic Stroke: Implications for Lesion-Symptom Mapping and Functional MRI |
| title_sort | cerebral perfusion in chronic stroke implications for lesion symptom mapping and functional mri |
| url | http://dx.doi.org/10.3233/BEN-2011-0283 |
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