Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population
ABSTRACT Long‐term visit‐to‐visit blood pressure (BP) variability is linked to various diseases, but its impact on cerebral small vessel disease (cSVD) burden, and its features remains uncertain. We analyzed 1284 participants from the Kailuan cohort (2006–2022). Visit‐to‐visit systolic BP (SBP), dia...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14943 |
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| author | Xinyu Zhao Ying Hui Jing Li Xian‐Quan Shi Shuohua Chen Han Lv Shouling Wu Zhenchang Wang |
| author_facet | Xinyu Zhao Ying Hui Jing Li Xian‐Quan Shi Shuohua Chen Han Lv Shouling Wu Zhenchang Wang |
| author_sort | Xinyu Zhao |
| collection | DOAJ |
| description | ABSTRACT Long‐term visit‐to‐visit blood pressure (BP) variability is linked to various diseases, but its impact on cerebral small vessel disease (cSVD) burden, and its features remains uncertain. We analyzed 1284 participants from the Kailuan cohort (2006–2022). Visit‐to‐visit systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) variability were categorized into tertiles (low, middle, high). Magnetic resonance imaging identified white matter hyperintensities (WMH), lacunae of presumed vascular origin (LA), cerebral microbleeds (CMBs), and visible perivascular spaces (PVS). Total cSVD burden was classified as none (0), mild (1), moderate (2), or severe (3–4) based on the presence of these features. Logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs). High SBP variability was associated with moderate cSVD burden (OR = 1.89, 95% CI: 1.09–3.29) and PVS (OR = 1.62, 95% CI: 1.10–2.39). High DBP variability was associated with LA (OR = 1.74, 95% CI: 1.06–2.84). High PP variability showed a significant risk for severe cSVD burden (OR = 2.49, 95% CI: 1.34–4.63). These associations were modified by age and hypertension status. Among young adults (age < 60 years), high PP variability was associated with severe cSVD burden (OR = 3.33, 95% CI: 1.31–8.44), LA (OR = 3.02, 95% CI: 1.31–6.93), and PVS (OR = 1.86, 95% CI: 1.20–2.88). The risk effects of SBP and PP variability on cSVD burden were significant only in participants with hypertension. High long‐term visit‐to‐visit BP variability (BPV), particularly in combination with hypertension, is a significant risk factor for total cSVD. Special attention should be given to PP variability in younger adults. |
| format | Article |
| id | doaj-art-cb23041826ca4b40b7607451965c0d41 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-cb23041826ca4b40b7607451965c0d412025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14943Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General PopulationXinyu Zhao0Ying Hui1Jing Li2Xian‐Quan Shi3Shuohua Chen4Han Lv5Shouling Wu6Zhenchang Wang7Clinical Epidemiology and EBM Unit Beijing Clinical Research Institute Beijing Friendship Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Friendship Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua UniversityDepartment of Radiology, Department of ultrasound Beijing Friendship Hospital Capital Medical University Beijing ChinaDepartment of Cardiology Kailuan General Hospital Tangshan ChinaDepartment of Radiology Beijing Friendship Hospital Capital Medical University Beijing ChinaDepartment of Cardiology Kailuan General Hospital Tangshan ChinaDepartment of Radiology Beijing Friendship Hospital Capital Medical University Beijing ChinaABSTRACT Long‐term visit‐to‐visit blood pressure (BP) variability is linked to various diseases, but its impact on cerebral small vessel disease (cSVD) burden, and its features remains uncertain. We analyzed 1284 participants from the Kailuan cohort (2006–2022). Visit‐to‐visit systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) variability were categorized into tertiles (low, middle, high). Magnetic resonance imaging identified white matter hyperintensities (WMH), lacunae of presumed vascular origin (LA), cerebral microbleeds (CMBs), and visible perivascular spaces (PVS). Total cSVD burden was classified as none (0), mild (1), moderate (2), or severe (3–4) based on the presence of these features. Logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs). High SBP variability was associated with moderate cSVD burden (OR = 1.89, 95% CI: 1.09–3.29) and PVS (OR = 1.62, 95% CI: 1.10–2.39). High DBP variability was associated with LA (OR = 1.74, 95% CI: 1.06–2.84). High PP variability showed a significant risk for severe cSVD burden (OR = 2.49, 95% CI: 1.34–4.63). These associations were modified by age and hypertension status. Among young adults (age < 60 years), high PP variability was associated with severe cSVD burden (OR = 3.33, 95% CI: 1.31–8.44), LA (OR = 3.02, 95% CI: 1.31–6.93), and PVS (OR = 1.86, 95% CI: 1.20–2.88). The risk effects of SBP and PP variability on cSVD burden were significant only in participants with hypertension. High long‐term visit‐to‐visit BP variability (BPV), particularly in combination with hypertension, is a significant risk factor for total cSVD. Special attention should be given to PP variability in younger adults.https://doi.org/10.1111/jch.14943blood pressure variabilitycerebral microbleedscerebral small vessel diseaselacunae of presumed vascular originvisible perivascular spaceswhite matter hyperintensities |
| spellingShingle | Xinyu Zhao Ying Hui Jing Li Xian‐Quan Shi Shuohua Chen Han Lv Shouling Wu Zhenchang Wang Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population The Journal of Clinical Hypertension blood pressure variability cerebral microbleeds cerebral small vessel disease lacunae of presumed vascular origin visible perivascular spaces white matter hyperintensities |
| title | Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population |
| title_full | Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population |
| title_fullStr | Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population |
| title_full_unstemmed | Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population |
| title_short | Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population |
| title_sort | higher long term visit to visit blood pressure variability is associated with severe cerebral small vessel disease in the general population |
| topic | blood pressure variability cerebral microbleeds cerebral small vessel disease lacunae of presumed vascular origin visible perivascular spaces white matter hyperintensities |
| url | https://doi.org/10.1111/jch.14943 |
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