Role of Leukotrienes on Protozoan and Helminth Infections
Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bact...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/595694 |
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| author | Alexandre P. Rogerio Fernanda F. Anibal |
| author_facet | Alexandre P. Rogerio Fernanda F. Anibal |
| author_sort | Alexandre P. Rogerio |
| collection | DOAJ |
| description | Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. Interestingly, some proteins from the saliva of insect vectors that transmit protozoans and secreted protein from helminth could bind LTs and may consequently modulate the course of infection or pathogenesis. In addition, the decreased production of LTs in immunocompromised individuals might modulate the pathophysiology of helminth and protozoan infections. Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections. |
| format | Article |
| id | doaj-art-cb128a064d744fee952a701fae172134 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cb128a064d744fee952a701fae1721342025-02-03T05:47:57ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/595694595694Role of Leukotrienes on Protozoan and Helminth InfectionsAlexandre P. Rogerio0Fernanda F. Anibal1Laboratory of Experimental Immunopharmacology, Federal University of Triângulo Mineiro, Rua Vigário Carlos, 162. 38025-380 Uberaba, MG, BrazilDepartment of Morphology and Pathology, Federal University of São Carlos, Rodovia Washington Luis, km 235 Caixa Postal 676, 13565-905 São Carlos, SP, BrazilLeukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. Interestingly, some proteins from the saliva of insect vectors that transmit protozoans and secreted protein from helminth could bind LTs and may consequently modulate the course of infection or pathogenesis. In addition, the decreased production of LTs in immunocompromised individuals might modulate the pathophysiology of helminth and protozoan infections. Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections.http://dx.doi.org/10.1155/2012/595694 |
| spellingShingle | Alexandre P. Rogerio Fernanda F. Anibal Role of Leukotrienes on Protozoan and Helminth Infections Mediators of Inflammation |
| title | Role of Leukotrienes on Protozoan and Helminth Infections |
| title_full | Role of Leukotrienes on Protozoan and Helminth Infections |
| title_fullStr | Role of Leukotrienes on Protozoan and Helminth Infections |
| title_full_unstemmed | Role of Leukotrienes on Protozoan and Helminth Infections |
| title_short | Role of Leukotrienes on Protozoan and Helminth Infections |
| title_sort | role of leukotrienes on protozoan and helminth infections |
| url | http://dx.doi.org/10.1155/2012/595694 |
| work_keys_str_mv | AT alexandreprogerio roleofleukotrienesonprotozoanandhelminthinfections AT fernandafanibal roleofleukotrienesonprotozoanandhelminthinfections |