Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura
Background. Visual symptoms are common in patients with migraine, even in interictal periods. The purpose was to assess the association between dynamic functional connectivity (dFC) of the visual cortex and clinical characteristics in migraine without aura (MwoA) patients. Methods. We enrolled fifty...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/9941832 |
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| author | Heng-Le Wei Tian Tian Gang-Ping Zhou Jin-Jin Wang Xi Guo Yu-Chen Chen Yu-Sheng Yu Xindao Yin Junrong Li Hong Zhang |
| author_facet | Heng-Le Wei Tian Tian Gang-Ping Zhou Jin-Jin Wang Xi Guo Yu-Chen Chen Yu-Sheng Yu Xindao Yin Junrong Li Hong Zhang |
| author_sort | Heng-Le Wei |
| collection | DOAJ |
| description | Background. Visual symptoms are common in patients with migraine, even in interictal periods. The purpose was to assess the association between dynamic functional connectivity (dFC) of the visual cortex and clinical characteristics in migraine without aura (MwoA) patients. Methods. We enrolled fifty-five MwoA patients as well as fifty gender- and age-matched healthy controls. Regional visual cortex alterations were investigated using regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF). Then, significant regions were selected as seeds for conducting dFC between the visual cortex and the whole brain. Results. Relative to healthy controls, MwoA patients exhibited decreased ReHo and ALFF values in the right lingual gyrus (LG) and increased ALFF values in the prefrontal cortex. The right LG showed abnormal dFC within the visual cortex and with other core brain networks. Additionally, ReHo values for the right LG were correlated with duration of disease and ALFF values of the right inferior frontal gyrus and middle frontal gyrus were correlated with headache frequency and anxiety scores, respectively. Moreover, the abnormal dFC of the right LG with bilateral cuneus was positively correlated with anxiety scores. Conclusions. The dFC abnormalities of the visual cortex may be involved in pain integration with multinetworks and associated with anxiety disorder in episodic MwoA patients. |
| format | Article |
| id | doaj-art-caf9321b649b4b4784be2a82b82b8e57 |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-caf9321b649b4b4784be2a82b82b8e572025-02-03T01:25:22ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/9941832Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without AuraHeng-Le Wei0Tian Tian1Gang-Ping Zhou2Jin-Jin Wang3Xi Guo4Yu-Chen Chen5Yu-Sheng Yu6Xindao Yin7Junrong Li8Hong Zhang9Department of RadiologyDepartment of NeurologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of NeurologyDepartment of RadiologyBackground. Visual symptoms are common in patients with migraine, even in interictal periods. The purpose was to assess the association between dynamic functional connectivity (dFC) of the visual cortex and clinical characteristics in migraine without aura (MwoA) patients. Methods. We enrolled fifty-five MwoA patients as well as fifty gender- and age-matched healthy controls. Regional visual cortex alterations were investigated using regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF). Then, significant regions were selected as seeds for conducting dFC between the visual cortex and the whole brain. Results. Relative to healthy controls, MwoA patients exhibited decreased ReHo and ALFF values in the right lingual gyrus (LG) and increased ALFF values in the prefrontal cortex. The right LG showed abnormal dFC within the visual cortex and with other core brain networks. Additionally, ReHo values for the right LG were correlated with duration of disease and ALFF values of the right inferior frontal gyrus and middle frontal gyrus were correlated with headache frequency and anxiety scores, respectively. Moreover, the abnormal dFC of the right LG with bilateral cuneus was positively correlated with anxiety scores. Conclusions. The dFC abnormalities of the visual cortex may be involved in pain integration with multinetworks and associated with anxiety disorder in episodic MwoA patients.http://dx.doi.org/10.1155/2022/9941832 |
| spellingShingle | Heng-Le Wei Tian Tian Gang-Ping Zhou Jin-Jin Wang Xi Guo Yu-Chen Chen Yu-Sheng Yu Xindao Yin Junrong Li Hong Zhang Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura Neural Plasticity |
| title | Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura |
| title_full | Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura |
| title_fullStr | Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura |
| title_full_unstemmed | Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura |
| title_short | Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura |
| title_sort | disrupted dynamic functional connectivity of the visual network in episodic patients with migraine without aura |
| url | http://dx.doi.org/10.1155/2022/9941832 |
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