Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia
Aims. Diabetes mellitus is a growing health problem worldwide. This study aimed to describe dysglycaemia and determine the impact of body composition and clinical and lifestyle factors on the risk of progression or regression from impaired fasting glucose (IFG) to diabetes or normoglycaemia in Austr...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/373762 |
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| author | L. de Abreu Kara L. Holloway Mark A. Kotowicz Julie A. Pasco |
| author_facet | L. de Abreu Kara L. Holloway Mark A. Kotowicz Julie A. Pasco |
| author_sort | L. de Abreu |
| collection | DOAJ |
| description | Aims. Diabetes mellitus is a growing health problem worldwide. This study aimed to describe dysglycaemia and determine the impact of body composition and clinical and lifestyle factors on the risk of progression or regression from impaired fasting glucose (IFG) to diabetes or normoglycaemia in Australian women. Methods. This study included 1167 women, aged 20–94 years, enrolled in the Geelong Osteoporosis Study. Multivariable logistic regression was used to identify predictors for progression to diabetes or regression to normoglycaemia (from IFG), over 10 years of follow-up. Results. At baseline the proportion of women with IFG was 33.8% and 6.5% had diabetes. Those with fasting dysglycaemia had higher obesity-related factors, lower serum HDL cholesterol, and lower physical activity. Over a decade, the incidence of progression from IFG to diabetes was 18.1 per 1,000 person-years (95% CI, 10.7–28.2). Fasting plasma glucose and serum triglycerides were important factors in both progression to diabetes and regression to normoglycaemia. Conclusions. Our results show a transitional process; those with IFG had risk factors intermediate to normoglycaemics and those with diabetes. This investigation may help target interventions to those with IFG at high risk of progression to diabetes and thereby prevent cases of diabetes. |
| format | Article |
| id | doaj-art-caf09136cdf14b4098bbe9f69948986f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-caf09136cdf14b4098bbe9f69948986f2025-02-03T01:22:19ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/373762373762Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or NormoglycaemiaL. de Abreu0Kara L. Holloway1Mark A. Kotowicz2Julie A. Pasco3School of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, AustraliaSchool of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, AustraliaSchool of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, AustraliaSchool of Medicine, Deakin University, 285 Ryrie Street, Geelong, VIC 3220, AustraliaAims. Diabetes mellitus is a growing health problem worldwide. This study aimed to describe dysglycaemia and determine the impact of body composition and clinical and lifestyle factors on the risk of progression or regression from impaired fasting glucose (IFG) to diabetes or normoglycaemia in Australian women. Methods. This study included 1167 women, aged 20–94 years, enrolled in the Geelong Osteoporosis Study. Multivariable logistic regression was used to identify predictors for progression to diabetes or regression to normoglycaemia (from IFG), over 10 years of follow-up. Results. At baseline the proportion of women with IFG was 33.8% and 6.5% had diabetes. Those with fasting dysglycaemia had higher obesity-related factors, lower serum HDL cholesterol, and lower physical activity. Over a decade, the incidence of progression from IFG to diabetes was 18.1 per 1,000 person-years (95% CI, 10.7–28.2). Fasting plasma glucose and serum triglycerides were important factors in both progression to diabetes and regression to normoglycaemia. Conclusions. Our results show a transitional process; those with IFG had risk factors intermediate to normoglycaemics and those with diabetes. This investigation may help target interventions to those with IFG at high risk of progression to diabetes and thereby prevent cases of diabetes.http://dx.doi.org/10.1155/2015/373762 |
| spellingShingle | L. de Abreu Kara L. Holloway Mark A. Kotowicz Julie A. Pasco Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia Journal of Diabetes Research |
| title | Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia |
| title_full | Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia |
| title_fullStr | Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia |
| title_full_unstemmed | Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia |
| title_short | Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia |
| title_sort | dysglycaemia and other predictors for progression or regression from impaired fasting glucose to diabetes or normoglycaemia |
| url | http://dx.doi.org/10.1155/2015/373762 |
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