PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting
TNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). The aim of the study was to assess whether polymorphisms of the TNFα (-308G>A) and PPARG2 (Pro12Ala) genes are associated with the risk of...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2019/1932036 |
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| author | Izabela Wojtkowska Tomasz A. Bonda Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Maria M. Winnicka Janina Stępińska |
| author_facet | Izabela Wojtkowska Tomasz A. Bonda Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Maria M. Winnicka Janina Stępińska |
| author_sort | Izabela Wojtkowska |
| collection | DOAJ |
| description | TNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). The aim of the study was to assess whether polymorphisms of the TNFα (-308G>A) and PPARG2 (Pro12Ala) genes are associated with the risk of developing HF by patients with ischemic heart disease. Methods. 122 patients without HF (aged 63 ± 8.8 years, 85% males) with confirmed coronary artery disease qualified for coronary bypass grafting were enrolled in the study. After the procedure, they were screened for cardiac parameters. Those with elevated NT-proBNP or diminished left ventricular ejection fraction during follow-up were assigned to the HF group (n=78), and the remaining ones to the non-HF group (n=44). The TNFα -308G>A and PPARG2 Pro12Ala polymorphisms were detected using the TaqMan method. Results. The distributions of TNFα -308G>A and PPARG2 Pro12Ala did not differ between the HF and non-HF groups (-308G>A: 16% vs. 11.4% of alleles; Pro12Ala: 23.9% vs. 20.5% of alleles, respectively). IL-6 concentration in the plasma of TNFα A-allele carriers at months 1 and 12 after CABG was higher in the HF group compared to the non-HF group (1 month after CABG: 5.3 ± 3.4 vs. 3.1 ± 2.9, p<0.05; 12 months after CABG: 4.2 ± 3,9 vs. 1.4 ± 1.2, p<0.01, respectively). Both polymorphisms were not related to changes in the plasma TNFα concentration or other parameters related to HF. Conclusions. Our study did not reveal any correlation between the PPARG2 Pro12Ala and TNFα -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting. |
| format | Article |
| id | doaj-art-cae294f1d5ed4f40932834c80f64de85 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-cae294f1d5ed4f40932834c80f64de852025-02-03T01:23:25ZengWileyPPAR Research1687-47571687-47652019-01-01201910.1155/2019/19320361932036PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass GraftingIzabela Wojtkowska0Tomasz A. Bonda1Andrzej Tysarowski2Katarzyna Seliga3Janusz A. Siedlecki4Maria M. Winnicka5Janina Stępińska6Institute of Cardiology, Intensive Cardiac Therapy Clinic, Alpejska St., 04-628 Warsaw, PolandMedical University of Bialystok, Department of General and Experimental Pathology, Mickiewicza 2c, 15-222 Bialystok, PolandInstitute of Oncology, Department of Molecular and Translational Oncology, Wawelska 15B St., 02-034 Warsaw, PolandInstitute of Oncology, Department of Molecular and Translational Oncology, Wawelska 15B St., 02-034 Warsaw, PolandInstitute of Oncology, Department of Molecular and Translational Oncology, Wawelska 15B St., 02-034 Warsaw, PolandMedical University of Bialystok, Department of General and Experimental Pathology, Mickiewicza 2c, 15-222 Bialystok, PolandInstitute of Cardiology, Intensive Cardiac Therapy Clinic, Alpejska St., 04-628 Warsaw, PolandTNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). The aim of the study was to assess whether polymorphisms of the TNFα (-308G>A) and PPARG2 (Pro12Ala) genes are associated with the risk of developing HF by patients with ischemic heart disease. Methods. 122 patients without HF (aged 63 ± 8.8 years, 85% males) with confirmed coronary artery disease qualified for coronary bypass grafting were enrolled in the study. After the procedure, they were screened for cardiac parameters. Those with elevated NT-proBNP or diminished left ventricular ejection fraction during follow-up were assigned to the HF group (n=78), and the remaining ones to the non-HF group (n=44). The TNFα -308G>A and PPARG2 Pro12Ala polymorphisms were detected using the TaqMan method. Results. The distributions of TNFα -308G>A and PPARG2 Pro12Ala did not differ between the HF and non-HF groups (-308G>A: 16% vs. 11.4% of alleles; Pro12Ala: 23.9% vs. 20.5% of alleles, respectively). IL-6 concentration in the plasma of TNFα A-allele carriers at months 1 and 12 after CABG was higher in the HF group compared to the non-HF group (1 month after CABG: 5.3 ± 3.4 vs. 3.1 ± 2.9, p<0.05; 12 months after CABG: 4.2 ± 3,9 vs. 1.4 ± 1.2, p<0.01, respectively). Both polymorphisms were not related to changes in the plasma TNFα concentration or other parameters related to HF. Conclusions. Our study did not reveal any correlation between the PPARG2 Pro12Ala and TNFα -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.http://dx.doi.org/10.1155/2019/1932036 |
| spellingShingle | Izabela Wojtkowska Tomasz A. Bonda Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Maria M. Winnicka Janina Stępińska PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting PPAR Research |
| title | PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting |
| title_full | PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting |
| title_fullStr | PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting |
| title_full_unstemmed | PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting |
| title_short | PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting |
| title_sort | pparg2 pro12ala and tnfα 308g a polymorphisms are not associated with heart failure development in patients with ischemic heart disease after coronary artery bypass grafting |
| url | http://dx.doi.org/10.1155/2019/1932036 |
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